Comparative Study of Adeno-associated Virus, Adenovirus, Bacu lovirus and Lentivirus Vectors for Gene Therapy of the Eyes

Kalesnykas Giedrius; Kokki Emmi; Alasaarela Laura; Lesch Hanna P.; Tuulos Timo; Kinnunen Kati; Uusitalo Hannu; Airenne Kari; Yla-Herttuala Seppo

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Comparative Study of Adeno-associated Virus, Adenovirus, Bacu lovirus and Lentivirus Vectors for Gene Therapy of the Eyes

机译：腺癌病毒，腺病毒，芽孢杆菌和慢病毒载体对眼睛基因治疗的比较研究

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Background: The eye possesses unique anatomical features that make it a valuable target for gene therapy applications.

机译：背景：眼睛具有独特的解剖特征，使其成为基因治疗应用的有价值的目标。

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来源
《Current gene therapy》 |2017年第3期|共13页
作者
Kalesnykas Giedrius; Kokki Emmi; Alasaarela Laura; Lesch Hanna P.; Tuulos Timo; Kinnunen Kati; Uusitalo Hannu; Airenne Kari; Yla-Herttuala Seppo;
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作者单位

Expt Ltd Microkatu 1 Kuopio 70211 Finland;

Univ Eastern Finland AI Virtanen Inst Mol Sci POB 1627 Kuopio 70211 Finland;

Univ Eastern Finland AI Virtanen Inst Mol Sci POB 1627 Kuopio 70211 Finland;

Univ Eastern Finland AI Virtanen Inst Mol Sci POB 1627 Kuopio 70211 Finland;

Kuopio Univ Hosp Dept Ophthalmol Kuopio 70211 Finland;

Kuopio Univ Hosp Dept Ophthalmol Kuopio 70211 Finland;

Univ Tampere Dept Ophthalmol Tampere Finland;

Univ Eastern Finland AI Virtanen Inst Mol Sci POB 1627 Kuopio 70211 Finland;

Univ Eastern Finland AI Virtanen Inst Mol Sci POB 1627 Kuopio 70211 Finland;

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原文格式 PDF
正文语种 eng
中图分类治疗学;
关键词
Gene therapy; Viral vectors; Intravitreal; Biodistribution; Eye; Transduction;

机译：基因疗法;病毒载体;玻璃体内;生物分布;眼睛;转导;

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1. Comparative Study of Adeno-associated Virus, Adenovirus, Bacu lovirus and Lentivirus Vectors for Gene Therapy of the Eyes [J] . Kalesnykas Giedrius, Kokki Emmi, Alasaarela Laura, Current gene therapy . 2017,第3期

机译：腺癌病毒，腺病毒，芽孢杆菌和慢病毒载体对眼睛基因治疗的比较研究
2. Efficacy and safety of myocardial gene transfer of adenovirus, adeno-associated virus and lentivirus vectors in the mouse heart [J] . Merentie M., Lottonen-Raikaslehto L., Parviainen V., Gene therapy . 2016,第3期

机译：腺病毒，腺相关病毒和慢病毒载体在小鼠心脏中心肌基因转移的功效和安全性
3. Towards a neuroprotective gene therapy for Parkinson's disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model. [J] . Bjorklund A, Kirik D, Rosenblad C, Brain research . 2000,第1a2期

机译：寻求针对帕金森氏病的神经保护基因疗法：使用腺病毒，AAV和慢病毒载体将GDNF的基因转移至大鼠帕金森氏症的黑质纹状体系统。
4. Purification of Aav Gene Therapy Vectors by Selectively Inactivating Helper Adenovirus Using High Hydrostatic Pressure [C] . Antonio Delgado, Peter Ferstl, Joshua N. Leonard International Symposium on Runaway Reactions, Pressure Relief Design and Effluent Handling American Institute of Chemical Engineers/American Chemical Society Management Conference . 2005

机译：用高静压压力选择性地灭活辅助腺病毒纯化AAV基因治疗载体
5. The establishment of an adenovirus-aprt vector system and the study of its application for human gene therapy. [D] . Wang, Qing. 1992

机译：腺病毒-aprt载体系统的建立及其在人类基因治疗中的应用研究。
6. Immune Responses to Adenovirus and Adeno-Associated Vectors Used for Gene Therapy of Brain Diseases: The Role of Immunological Synapses in Understanding the Cell Biology of Neuroimmune Interactions [O] . Pedro R. Lowenstein, Ronald J. Mandel, Wei-dong Xiong, -1

机译：对用于脑疾病基因治疗的腺病毒和腺相关载体的免疫应答：免疫突触在理解神经免疫相互作用的细胞生物学中的作用。
7. Efficacy and safety of myocardial gene transfer of adenovirus, adeno-associated virus and lentivirus vectors in the mouse heart [O] . M Merentie, L Lottonen-Raikaslehto, V Parviainen, 2015

机译：小鼠心脏腺病毒，腺瘤相关病毒和慢病毒载体心肌基因转移的疗效和安全性
8. Vasculature-Specific Adenovirus Vectors for Gene Therapy of Prostate Cancer; Final rept. 1 Feb 2004-31 Jan 2008 [R] . Krasnykh, V. 2008

机译：用于前列腺癌基因治疗的脉管系统特异性腺病毒载体;最终的评论。 2004年2月1日至2008年1月31日

Comparative Study of Adeno-associated Virus, Adenovirus, Bacu lovirus and Lentivirus Vectors for Gene Therapy of the Eyes

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