Role of Nanomedicine in Treatment of Brain Cancer | Bentham Science

摘要

Drug delivery to cancerous brain is a challenging task as it issurrounded by an efficient protective barrier. The main hurdles for delivery of bioactivemolecules to cancerous brain are blood brain barrier (BBB), the invasive nature of gliomas,drug resistance, and difficult brain interstitium transportation. Therefore, treatmentof brain cancer with the available drug regimen is difficult and has shown little improvementin recent years.Methods: We searched about recent advancements in the use of nanomedicine for effectivetreatment of the brain cancer. We focused on the use of liposomes, nanoparticles,polymeric micelles, and dendrimers to improve brain cancer therapy.Results: Nanomedicines are well suited for the treatment of brain cancer owing to theirhighly acceptable biological, chemical, and physical properties. Smaller size of nanomedicinesalso enhances their anticancer potential and penetration into blood brain barrier(BBB).Conclusion: Recently, nanomedicine based approaches have been developed and investigatedfor effective treatment of brain cancer. Some of these have been translated intoclinical practice, in order to attain therapeutic needs of gliomas. Future advancements innanomedicines will likely produce significant changes in methods and practice of braincancer therapy.