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Survival of patients with multiple brain metastases treated with whole-brain radiotherapy

机译:全脑放射治疗多重脑转移患者的存活

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Aim: To report the survival outcomes of patients with multiple brain metastases treated with whole-brain radiotherapy. Patients & methods: From 2004 to 2012, patients with brain metastases treated with whole-brain radiotherapy were included. Overall survival (OS) was calculated from the start of radiation treatment. Univariate and multivariate proportional hazard model of OS was conducted. Generalized R2 statistic (ranged from 0 to 1) was calculated to determine the association with the outcome. Results: Nine-hundred-ninety-one patients were included. The actuarial median OS time was 2.7 months (95% CI: 2.5-2.9). Patients of older age (>65 years), lower Karnofsky performance status, not postoperative and patients with gastrointestinal, genitourinary or lung as opposed to breast cancer were more likely to have a shorter survival. Conclusion: Short median survival of 2.7 months may reflect poorer prognosis of patients referred due to large amount of referrals for radiosurgery. Prognostic factors for survival should be considered at consultation.
机译:目的:报告用全脑放射治疗多重脑转移患者的存活结果。患者及方法:从2004年到2012年,包括用全脑放射治疗的脑转移患者。从放射治疗开始计算总存活(OS)。进行操作系统的单变量和多变量比例危害模型。计算出来的广义R2统计(范围为0至1)以确定与结果的关联。结果:包括九九十一患者。精算中位数OS时间为2.7个月(95%CI:2.5-2.9)。年龄较大的患者(> 65岁),降低Karnofsky性能状况,而不是术后和胃肠道,泌尿生殖或肺等患者而不是乳腺癌的患者更可能生存较短。结论:27个月的短中位数存活可能反映由于放射外科的大量推荐患者的患者预后较差。应在咨询中考虑生存的预后因素。

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