Self-nanoemulsifying drug delivery systems of myricetin: Formulation development, characterization, and in vitro and in vivo evaluation

摘要

Graphical abstractDisplay OmittedHighlights?Four Myr-SNEDDS with different characteristics were successfully prepared and evaluated.?The components and ratios of each component had influence on the properties of each SNEDDS formulation.?Myr-SNEDDS can improve the solubility and permeability of Myr.?The SNEDDS can improve the bioavailability of insoluble herbal drugs like Myr.AbstractDespite various pharmacological effects, myricetin (Myr) shows low oral bioavailability (<10%) due to its poor solubility, which limits its applications. To address this problem, self-nanoemulsifying drug delivery systems