Nano-structural comparison of 2-methacryloyloxyethyl phosphorylcholine- and ethylene glycol-based surface modification for preventing protein and cell adhesion

摘要

Graphical abstractDisplay OmittedHighlights?The brush structure of MPC and EG units prevented protein and cell adhesion regardless of their density.?Multiple polymer layers formed by MPC-based polymer coating showed similar anti-biofouling property with brush structure.?Single layered EG-based polymer coating was not stable enough for complete prevention of protein and cell adhesion.?Monomer monolayer of MPC could suppress protein adsorption only under the low concentration.?The volume excluded by the polymer structure was not only important in EG units-based surface, but also in MPC-based surface.展开▼