Novel Thiazole-Based Thiazolidinones as Potent Anti-infective Agents: In silica PASS and Toxicity Prediction, Synthesis, Biological Evaluation and Molecular Modelling

摘要

Aims and Objective: The infectious disease treatment remains a challenging concern owing to the increasing number of pathogenic microorganisms associated with resistance to multiple drugs. A promising approach for combating microbial infection is to combine two or more known bioactive heterocyclic pharmacophores in one molecular platform. Herein, the synthesis and biological evaluation of novel thiazole-thiazolidinone hybrids as potential antimicrobial agents were dissimilated.