A High-throughput Screening of a Chemical Compound Library in Ovarian Cancer Stem Cells

Ricci F.; Carrassa L.; Christodoulou M. S.; Passarella D.; Michel B.; Benhida R.; Martinet N.; Hunyadi A.; Ioannou E.; Roussis V.; Musso L.; Dallavalle S.; Silvestri R.; Westwood N.; Mori M.; Ingallina C.; Botta B.; Kavetsou E.; Detsi A.; Majer Z.; Hudecz F.; Bosze S.; Kaminska B.; Hansen T. V.; Bertrand P.; Athanassopoulos C. M.; Damia G.

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A High-throughput Screening of a Chemical Compound Library in Ovarian Cancer Stem Cells

机译：卵巢癌干细胞中化合物文库的高通量筛选

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Background: Epithelial ovarian cancer has a poor prognosis, mostly due to its late diagnosis and the development of drug resistance after a first platinum-based regimen. The presence of a specific population of "cancer stem cells" could be responsible of the relapse of the tumor and the development of resistance to therapy. For this reason, it would be important to specifically target this subpopulation of tumor cells in order to increase the response to therapy.

机译：背景：上皮性卵巢癌预后差，主要是由于其延迟诊断和耐药后的耐药性，在第一个基于铂族的方案之后。特异性群体的“癌症干细胞”的存在可能是肿瘤的复发和抗治疗抗性的转发。因此，重要的是特别靶向肿瘤细胞的这种亚群以增加对治疗的反应。

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来源
《Combinatorial chemistry & high throughput screening》 |2018年第1期|共7页
作者
Ricci F.; Carrassa L.; Christodoulou M. S.; Passarella D.; Michel B.; Benhida R.; Martinet N.; Hunyadi A.; Ioannou E.; Roussis V.; Musso L.; Dallavalle S.; Silvestri R.; Westwood N.; Mori M.; Ingallina C.; Botta B.; Kavetsou E.; Detsi A.; Majer Z.; Hudecz F.; Bosze S.; Kaminska B.; Hansen T. V.; Bertrand P.; Athanassopoulos C. M.; Damia G.;
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作者单位

IRCCS Ist Ric Farmacol Mario Negri Via Giuseppe La Masa 19 I-20156 Milan Italy;

IRCCS Ist Ric Farmacol Mario Negri Via Giuseppe La Masa 19 I-20156 Milan Italy;

Univ Milan Dipartimento Chim Via C Golgi 19 I-20133 Milan Italy;

Univ Milan Dipartimento Chim Via C Golgi 19 I-20133 Milan Italy;

Univ Cote dAzur CNRS Inst Chim Nice UMR 7272 F-06108 Nice France;

Univ Cote dAzur CNRS Inst Chim Nice UMR 7272 F-06108 Nice France;

Univ Cote dAzur CNRS Inst Chim Nice UMR 7272 F-06108 Nice France;

Univ Szeged Inst Pharmacognosy Eotvos Str 6 Szeged Hungary;

Univ Athens Dept Pharm Sect Pharmacognosy &

Chem Nat Prod Athens 15771 Greece;

Univ Athens Dept Pharm Sect Pharmacognosy &

Chem Nat Prod Athens 15771 Greece;

Univ Milan Dept Food Environm &

Nutr Sci I-20133 Milan Italy;

Univ Milan Dept Food Environm &

Nutr Sci I-20133 Milan Italy;

Sapienza Univ Roma Dipartimento Chim &

Tecnol Farmaco Piazzale Aldo Moro 5 I-00185 Rome Italy;

Univ St Andrews Sch Chem Biomed Sci Res Complex St Andrews KY16 Fife Scotland;

Ctr Life Nano Sci Sapienza Ist Italiano Tecnol Viale Regina Elena 291 I-00161 Rome Italy;

Sapienza Univ Roma Dipartimento Chim &

Tecnol Farmaco Piazzale Aldo Moro 5 I-00185 Rome Italy;

Sapienza Univ Roma Dipartimento Chim &

Tecnol Farmaco Piazzale Aldo Moro 5 I-00185 Rome Italy;

Natl Tech Univ Athens Sch Chem Engn Dept Chem Sci Iroon Politechniou 9 Zografou Campus Athens;

Natl Tech Univ Athens Sch Chem Engn Dept Chem Sci Iroon Politechniou 9 Zografou Campus Athens;

Eotvos Lorand Univ Dept Organ Chem H-1117 Budapest Hungary;

Eotvos Lorand Univ Dept Organ Chem H-1117 Budapest Hungary;

Eotvos Lorand Univ Hungarian Acad Sci Res Grp Peptide Chem H-1117 Budapest Hungary;

Polish Acdemy Sci Nencki Inst Expt Biol Mol Neurobiol Lab Neurobiol Ctr Pasteur 3 Str PL-02093;

Univ Oslo Dept Pharmaceut Chem Sch Pharm N-0316 Oslo Norway;

UMR CNRS 7285 Inst Chim Milieux &

Mat Poitiers F-86000 Poitiers France;

Univ Patras Dept Chem Patras Greece;

IRCCS Ist Ric Farmacol Mario Negri Via Giuseppe La Masa 19 I-20156 Milan Italy;

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原文格式 PDF
正文语种 eng
中图分类化学;
关键词
Cancer stem cell; chemical compounds library; oncology screening; high-throughput screening; ovarian cancer; therapy resistance;

机译：癌症干细胞;化合物文库;肿瘤学筛查;高通量筛选;卵巢癌;治疗抵抗;

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专利

1. A High-throughput Screening of a Chemical Compound Library in Ovarian Cancer Stem Cells [J] . Ricci F., Carrassa L., Christodoulou M. S., Combinatorial chemistry & high throughput screening . 2018,第1期

机译：卵巢癌干细胞中化合物文库的高通量筛选
2. High-Throughput Screening of One-Bead-One-Compound Peptide Libraries Using Intact Cells [J] . Choi-Fong Cho, Babak Behnam Azad, Leonard G. Luyt ACS combinatorial science . 2013,第8期

机译：使用完整细胞的一珠一化合物肽库的高通量筛选
3. Quantitative High-Throughput Screening Using an Organotypic Model Identifies Compounds that Inhibit Ovarian Cancer Metastasis [J] . Kenny Hilary A., Lal-Nag Madhu, Shen Min, Molecular cancer therapeutics . 2020,第1期

机译：使用有机型模型的定量高通量筛选鉴定了抑制卵巢癌转移的化合物
4. HIGH-THROUGHPUT SCREENING OF CHEMICAL LIBRARIES FOR MODULATORS OF MESENCHYMAL STEM CELL CHONDROGENESIS [C] . Alice H. Huang, Nuzhat A. Motlekar, Ashley Stein, ASME summer bioengineering conference;SBC2008 . 2009

机译：间充质干细胞软骨形成调节剂化学文库的高通量筛选
5. Identification of Licofelone Through Three-Dimensional Cell Culture Drug Screening as a Repurposed Agent Able to Reverse Drug Resistant and Cancer Stem Cell-like Subpopulations in Ovarian Cancer [D] . Hirst, Jeffrey J. 2017

机译：通过三维细胞培养药物筛选作为一种能够逆转卵巢癌的耐药性和癌症干细胞样亚群的改用药物，鉴定力费龙
6. Identification of inhibitors of ovarian cancer stem-like cells by high-throughput screening [O] . Roman Mezencev, Lijuan Wang, John F McDonald 2012

机译：通过高通量筛选鉴定卵巢癌干样细胞抑制剂
7. A High-throughput Screening of a Chemical Compound Library in Ovarian Cancer Stem Cells [O] . F. Ricci, L. Carrassa, M. S. Christodoulou, 2018

机译：卵巢癌干细胞中化合物文库的高通量筛选
8. Development and Screening of Subtractive RNAi Libraries from Ovarian Cancer Cell Lines [R] . Dimtchev, A. B. 2009

机译：从卵巢癌细胞系开发和筛选消减RNai文库

A High-throughput Screening of a Chemical Compound Library in Ovarian Cancer Stem Cells

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