New and Novel Agents Targeting Resistant Gram-Negative Bacteria: A Review for the Clinical Microbiologist

摘要

Several new antimicrobial agents with activity against Gram-negative bacteria have been approved by the Food and Drug Administration or are in late development. This review discusses the mode of action, spectrum of activity, resistance mechanism(s), and testing considerations for ceftolozane-tazobactam, ceftazidime-avibactam, meropenem-vaborbactam, delafloxacin, and plazomicin. Agents with activity against Gram-negative bacteria that are in late-phase development are also described.