Higher level of GGT GGT during mid‐pregnancy is associated with increased risk of gestational diabetes mellitus

摘要

Summary Objective This study was to explore the link between gamma‐glutamyl transferase ( GGT ), alanine transaminase ( ALT ) and aspartate transaminase ( AST ) levels during early‐middle pregnancy and subsequent risk of gestational diabetes mellitus ( GDM ). Methods In a prospective cohort study, pregnant women enrolled prior to 16?weeks of gestation were followed up until delivery. GGT , AST and ALT levels were tested during weeks 14‐18 of gestation and oral glucose tolerance test was conducted during 24‐28?weeks to screen GDM . Results The GDM rate was 8.1% (122/1512). Mean GGT level was higher in GDM than non‐ GDM women (18.7?±?13.0 vs 14.5?±?7.0, P? ? .001). The higher GGT level was 26.9~74.0 U/L, which was significantly associated with increased risk of GDM . The adjusted RR (95% CI ) comparing higher GGT level versus lower was 5.40 (3.36‐8.68). No significant correlation was found between ALT or AST levels and the risk of GDM . Conclusions The results suggest that pregnant women with higher serum GGT during early‐middle pregnancy have higher risk of developing GDM . A GGT level 26.9 U/L may indicate an increased risk of developing GDM later and should be further concerned.