The effect of maternal use of telbivudine on neonatal CD4(+)CD25(+) regulatory T cells for the prevention of mother-to-child transmission of hepatitis B virus

摘要

Antiviral treatment could block mother-to-child transmission (MTCT) of hepatitis B virus (HBV) effectively. We examined whether maternal use of telbivudine (LdT) could decrease the proportion of CD4(+)CD25(+) regulatory T cells and explored the immunological mechanism. A total of 89 pregnant women with HBsAg positive were enrolled, where 30 pregnant women with HBeAg negative (viral load = 10(6) IU/ml) were followed in the study. The women with high viral load were divided to the LdT-treated group where they were prescribed with 600 mg LdT daily (29 cases) during the third trimester of pregnancy or to the non-treated group (30 cases) on a voluntary basis. Samples of neonates were taken for analyzing CD4(+)CD25(+) Tregs with flow cytometric techniques. A more significant decrease in the proportion of CD4(+)CD25(+) Tregs in neonatal peripheral blood had been observed with maternal use of telbivudine (2.8%+/- 1.1%) than those without any treatment (7.0%+/- 1.6%, P < 0.01). None of the infants in the LdT-treated group were HBsAg positive at 7 months of age. In addition, neonates whose mothers received telbivudine had a significant improvement in cellular immune function, as indicated by the proportion of CD8(+) T cells. For HBV carriers with high viral load, maternal use of LdT may be useful in regulating neonatal immune function involved in mother-to-child transmission of hepatitis B virus. (C) 2019 Elsevier Masson SAS. All rights reserved.