Effect of two different sublingual dosages of vitamin B-12 on cobalamin nutritional status in vegans and vegetarians with a marginal deficiency: A randomized controlled trial

摘要

Background & aims: Vegetarians and vegans are more vulnerable to vitamin B-12 deficiency with severe risks of megaloblastic anemia, cognitive decline, neuropathy, and depression. An easy and simple method of supplementation consists of taking one weekly dosage of 2000 mu g. However, single large oral doses of vitamin B-12 are poorly absorbed. The present research evaluates the ability of two different sublingual dosages of vitamin B-12 (350 mu g/week vs 2000 mu g/week) in improving cyanocobalamin (vitamin B-12) nutritional status in vegans and vegetarians with a marginal deficiency.