Prediction of Normal Organ Absorbed Doses for [177Lu]Lu-PSMA-617 Using [44Sc]Sc-PSMA-617 Pharmacokinetics in Patients With Metastatic Castration Resistant Prostate Carcinoma

Khawar Ambreen; Eppard Elisabeth; Sinnes Jean Phlippe; Roesch Frank; Ahmadzadehfar Hojjat; Kuerpig Stefan; Meisenheimer Michael; Gaertner Florian C.; Essler Markus; Bundschuh Ralph A.

首页> 外文期刊>Clinical nuclear medicine >Prediction of Normal Organ Absorbed Doses for [177Lu]Lu-PSMA-617 Using [44Sc]Sc-PSMA-617 Pharmacokinetics in Patients With Metastatic Castration Resistant Prostate Carcinoma

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Prediction of Normal Organ Absorbed Doses for [177Lu]Lu-PSMA-617 Using [44Sc]Sc-PSMA-617 Pharmacokinetics in Patients With Metastatic Castration Resistant Prostate Carcinoma

机译：使用[177LU] Lu-PSMA-617的正常器官吸收剂量的预测使用[44M] SC-PSMA-617药代动力学耐转移阉割前列腺癌患者

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Aim In vivo pharmacokinetic analysis of [Sc-44]Sc-PSMA-617 was used to determine the normal organ-absorbed doses that may result from therapeutic activity of [Lu-177]Lu-PSMA-617 and to predict the maximum permissible activity of [Lu-177]Lu-PSMA-617 for patients with metastatic castration-resistant prostate carcinoma.

机译：用于[SC-44] SC-PSMA-617的体内药代动力学分析，用于确定可能由[LU-177] LU-PSMA-617的治疗活性产生的正常器官吸收剂量，并预测最大允许活动 [Lu-177] Lu-PSMA-617用于转移阉割阉割前列腺癌的患者。

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来源
《Clinical nuclear medicine》 |2018年第7期|共6页
作者
Khawar Ambreen; Eppard Elisabeth; Sinnes Jean Phlippe; Roesch Frank; Ahmadzadehfar Hojjat; Kuerpig Stefan; Meisenheimer Michael; Gaertner Florian C.; Essler Markus; Bundschuh Ralph A.;
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作者单位

Univ Med Ctr Bonn Dept Nucl Med Bonn Germany;

Univ Med Ctr Bonn Dept Nucl Med Bonn Germany;

Johannes Gutenberg Univ Mainz Inst Nucl Chem Mainz Germany;

Johannes Gutenberg Univ Mainz Inst Nucl Chem Mainz Germany;

Univ Med Ctr Bonn Dept Nucl Med Bonn Germany;

Univ Med Ctr Bonn Dept Nucl Med Bonn Germany;

Univ Med Ctr Bonn Dept Nucl Med Bonn Germany;

Univ Med Ctr Bonn Dept Nucl Med Bonn Germany;

Univ Med Ctr Bonn Dept Nucl Med Bonn Germany;

Univ Med Ctr Bonn Dept Nucl Med Bonn Germany;

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原文格式 PDF
正文语种 eng
中图分类放射医学;
关键词
Lu-177Lu-PSMA-617 therapy; Sc-44Sc-PSMA-617; dosimetric analysis; maximum permissible activity; normal organ-absorbed doses;

机译：[Lu-177] Lu-PSMA-617治疗;[SC-44] SC-PSMA-617;剂量分析;最大允许活动;正常器官吸收剂量;

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专利

1. Prediction of Normal Organ Absorbed Doses for [177Lu]Lu-PSMA-617 Using [44Sc]Sc-PSMA-617 Pharmacokinetics in Patients With Metastatic Castration Resistant Prostate Carcinoma [J] . Khawar Ambreen, Eppard Elisabeth, Sinnes Jean Phlippe, Clinical nuclear medicine . 2018,第7期

机译：使用[177LU] Lu-PSMA-617的正常器官吸收剂量的预测使用[44M] SC-PSMA-617药代动力学耐转移阉割前列腺癌患者
2. Radiation Dosimetry for 177Lu-PSMA I&T in Metastatic Castration-Resistant Prostate Cancer: Absorbed Dose in Normal Organs and Tumor Lesions [J] . Shozo Okamoto, Anne Thieme, Jakob Allmann, The Journal of Nuclear Medicine . 2017,第3期

机译：177Lu-PSMA I＆T在转移性去势抵抗性前列腺癌中的放射剂量测定：正常器官和肿瘤病变的吸收剂量
3. Radiation Dosimetry for Lu-177-PSMA I&T in Metastatic Castration-Resistant Prostate Cancer: Absorbed Dose in Normal Organs and Tumor Lesions [J] . Okamoto Shozo, Thieme Anne, Allmann Jakob, The Journal of Nuclear Medicine . 2017,第3期

机译：转移阉割抗阉割前列腺癌中Lu-177-PSMA I＆T的辐射剂量测定：正常器官和肿瘤病变中的吸收剂量
4. Metastatic Hormone-Sensitive and Castration-Resistant Prostate Cancer: A Decade of Progress and Ongoing Discoveries [C] . Leonel Hernez-Aya, Maha Hussain Genitourinary Cancers Symposium. . 2014

机译：转移激素敏感和阉割的前列腺癌：进步和持续发现的十年
5. Muscle Cross-Sectional Area Is Improved and Physical Funciton Is Maintained After Home-Based Exercise in Men with Metastatic Castration-Resistant Prostate Cancer Undergoing Androgen Deprivation Therapy [D] . Alzer, Mohamdod Saber. 2020

机译：改善肌横截面积，并且在具有转移阉割的前列腺癌接受雄激素剥夺治疗的男性中的男性锻炼之后，将物理静脉凝集维持
6. Pilot Study of Hyperfractionated Dosing of Lutetium‐177–Labeled Antiprostate‐Specific Membrane Antigen Monoclonal Antibody J591 (177Lu‐J591) for Metastatic Castration‐Resistant Prostate Cancer [O] . Muhammad Junaid Niaz, Jaspreet S. Batra, Ryan D. Walsh, 2020

机译：ute标记的抗前列腺特异性膜抗原单克隆抗体J591（177Lu-J591）超分割剂量用于转移性去势抵抗性前列腺癌的初步研究
7. Radiation Dosimetry for 177Lu-PSMA IT in Metastatic Castration-Resistant Prostate Cancer: Absorbed Dose in Normal Organs and Tumor Lesions [O] . Shozo Okamoto, Anne Thieme, Jakob Allmann, 2016

机译：177LU-PSMA I＆T在转移性阉割前列腺癌中的辐射剂量测定剂：正常器官和肿瘤病变中的吸收剂量

Prediction of Normal Organ Absorbed Doses for [177Lu]Lu-PSMA-617 Using [44Sc]Sc-PSMA-617 Pharmacokinetics in Patients With Metastatic Castration Resistant Prostate Carcinoma

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