Effects of the Proton Pump Inhibitors Omeprazole and Pantoprazole on the Cytochrome P450-Mediated Metabolism of Venlafaxine

Kuzin Maxim; Schoretsanitis Georgios; Haen Ekkehard; Stegmann Benedikt; Hiemke Christoph; Gruender Gerhard; Paulzen Michael

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Effects of the Proton Pump Inhibitors Omeprazole and Pantoprazole on the Cytochrome P450-Mediated Metabolism of Venlafaxine

机译：质子泵抑制剂Omeprazole和PantoPrazole对venlafaxine细胞色素P450介导的代谢的影响

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摘要

An increasing trend in prescribing proton pump inhibitors (PPIs) inevitably increases the risk of unwanted drug-drug interactions (DDIs). The aim of this study was to uncover pharmacokinetic interactions between two PPIs-omeprazole and pantoprazole-and venlafaxine.

机译：规定质子泵抑制剂（PPI）的增加趋势不可避免地增加了不需要的药物 - 药物相互作用（DDI）的风险。本研究的目的是发现两种PPIS-奥咪唑和泮托拉唑和羟类甲丙唑的药代动力学相互作用。

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《Clinical pharmacokinetics》 |2018年第6期|共9页
作者
Kuzin Maxim; Schoretsanitis Georgios; Haen Ekkehard; Stegmann Benedikt; Hiemke Christoph; Gruender Gerhard; Paulzen Michael;
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Rhein Westfal TH Aachen Dept Psychiat Psychotherapy &

Psychosomat Pauwelsstr 30 D-52074 Aachen;

Rhein Westfal TH Aachen Dept Psychiat Psychotherapy &

Psychosomat Pauwelsstr 30 D-52074 Aachen;

Univ Regensburg Dept Psychiat &

Psychotherapy Clin Pharmacol Regensburg Germany;

Univ Regensburg Dept Psychiat &

Psychotherapy Clin Pharmacol Regensburg Germany;

Univ Med Ctr Mainz Dept Psychiat &

Psychotherapy Mainz Germany;

Rhein Westfal TH Aachen Dept Psychiat Psychotherapy &

Psychosomat Pauwelsstr 30 D-52074 Aachen;

Rhein Westfal TH Aachen Dept Psychiat Psychotherapy &

Psychosomat Pauwelsstr 30 D-52074 Aachen;

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正文语种 eng
中图分类药理学;
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1. Effects of the Proton Pump Inhibitors Omeprazole and Pantoprazole on the Cytochrome P450-Mediated Metabolism of Venlafaxine [J] . Kuzin Maxim, Schoretsanitis Georgios, Haen Ekkehard, Clinical pharmacokinetics . 2018,第6期

机译：质子泵抑制剂Omeprazole和PantoPrazole对venlafaxine细胞色素P450介导的代谢的影响
2. The proton pump inhibitor, omeprazole, but not lansoprazole or pantoprazole, is a metabolism-dependent inhibitor of CYP2C19: implications for coadministration with clopidogrel. [J] . Ogilvie BW, Yerino P, Kazmi F, Drug Metabolism and Disposition: The Biological Fate of Chemicals . 2011,第11期

机译：质子泵抑制剂奥美拉唑（但不是兰索拉唑或pan托拉唑）是CYP2C19的代谢依赖性抑制剂：与氯吡格雷共同给药的意义。
3. Pharmacokinetics and effect on caffeine metabolism of the proton pump inhibitors, omeprazole, lansoprazole, and pantoprazole. [J] . Andersson T, Holmberg J, Rohss K, British Journal of Clinical Pharmacology . 1998,第4期

机译：质子泵抑制剂奥美拉唑，兰索拉唑和pan托拉唑的药代动力学及其对咖啡因代谢的影响。
4. Plant cytochrome P450-mediated herbicide metabolism [C] . Balazs Siminszky the Phytochemical Society of Europe Meeting . 2006

机译：植物细胞色素P450介导的除草剂代谢
5. Phytochemical variation in Canadian Hydrastis canadensis L. (goldenseal) and the in vitro inhibition of human cytochrome P450-mediated drug metabolism by H. canadensis and other botanicals. [D] . Leduc, Renee Irene. 2007

机译：加拿大Hydrastis canadensis L.（goldenseal）的植物化学变化以及加拿大H. canadensis和其他植物药对人细胞色素P450介导的药物代谢的体外抑制。
6. Pharmacokinetics and effect on caffeine metabolism of the proton pump inhibitors omeprazole lansoprazole and pantoprazole [O] . Tommy Andersson, Johan Holmberg, Kerstin Röhss, 1998

机译：质子泵抑制剂奥美拉唑兰索拉唑和pan托拉唑的药代动力学及其对咖啡因代谢的影响
7. The proton pump inhibitor, omeprazole, but not lansoprazole or pantoprazole, is a metabolism-dependent inhibitor of CYP2C19: Implications for coadministration with clopidogrel [O] . Ogilvie Brian W., Yerino Phyllis, Kazmi Faraz, 2011

机译：质子泵抑制剂奥美拉唑，但不是兰索拉唑或泮托拉唑，是CYp2C19的代谢依赖性抑制剂：与氯吡格雷共同给药的意义

Effects of the Proton Pump Inhibitors Omeprazole and Pantoprazole on the Cytochrome P450-Mediated Metabolism of Venlafaxine

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