A Phase III, Multicenter, Randomized, Double-blind, Active Comparator Clinical Trial to Compare the Efficacy and Safety of Combination Therapy With Ezetimibe and Rosuvastatin Versus Rosuvastatin Monotherapy in Patients With Hypercholesterolemia: I-ROSETTE (Ildong Rosuvastatin & Ezetimibe for Hypercholesterolemia) Randomized Controlled Trial

Hong Soon Jun; Jeong Han Saem; Ahn Jeong Cheon; Cha Dong-Hun; Won Kyung Heon; Kim Weon; Cho Sang Kyoon; Kim Seok-Yeon; Yoo Byung-Su; Sung Ki Chul; Rha Seung-Woon; Shin Joon-Han; Han Kyoo Rok; Chung Wook Sung; Hyon Min Su; Lee Han Cheol; Bae Jang-Ho; Rhee Moo-Yong; Kwan Jun; Jeon Dong Woon; Yoo Ki Dong; Kim Hyo-Soo

首页> 外文期刊>Clinical therapeutics >A Phase III, Multicenter, Randomized, Double-blind, Active Comparator Clinical Trial to Compare the Efficacy and Safety of Combination Therapy With Ezetimibe and Rosuvastatin Versus Rosuvastatin Monotherapy in Patients With Hypercholesterolemia: I-ROSETTE (Ildong Rosuvastatin & Ezetimibe for Hypercholesterolemia) Randomized Controlled Trial

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A Phase III, Multicenter, Randomized, Double-blind, Active Comparator Clinical Trial to Compare the Efficacy and Safety of Combination Therapy With Ezetimibe and Rosuvastatin Versus Rosuvastatin Monotherapy in Patients With Hypercholesterolemia: I-ROSETTE (Ildong Rosuvastatin & Ezetimibe for Hypercholesterolemia) Randomized Controlled Trial

机译：III期，多中心，随机，双盲，活性比较试验，以比较与ezetimibe和罗萨凡汀单一的高胆固醇血症患者的疗效和安全性的疗效和安全性：I-ROSETTE（ILDONGROSUVASTATIMIBE用于高胆固醇血症）随机控制审判

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Purpose: Combination therapy with ezetimibe and statins is recommended in cases of statin intolerance or insufficiency. The objective of this study was to compare the efficacy and safety of combination therapy with ezetimibe and rosuvastatin versus those of rosuvastatin monotherapy in patients with hypercholesterolemia.

机译：目的：在他汀类药物的不耐受或不符号的情况下，建议使用ezetimibe和他汀类药物的组合治疗。本研究的目的是比较与ezetimibe和roosuvastatin的组合治疗的疗效和安全性与高胆固醇血症患者的罗萨伐他汀单一治疗。

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《Clinical therapeutics》 |2018年第2期|共16页
作者
Hong Soon Jun; Jeong Han Saem; Ahn Jeong Cheon; Cha Dong-Hun; Won Kyung Heon; Kim Weon; Cho Sang Kyoon; Kim Seok-Yeon; Yoo Byung-Su; Sung Ki Chul; Rha Seung-Woon; Shin Joon-Han; Han Kyoo Rok; Chung Wook Sung; Hyon Min Su; Lee Han Cheol; Bae Jang-Ho; Rhee Moo-Yong; Kwan Jun; Jeon Dong Woon; Yoo Ki Dong; Kim Hyo-Soo;
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作者单位

Korea Univ Anam Hosp Dept Cardiol Cardiovasc Ctr Seoul South Korea;

Korea Univ Anam Hosp Dept Cardiol Cardiovasc Ctr Seoul South Korea;

Korea Univ Ansan Hosp Dept Internal Med Div Cardiol Ansan South Korea;

CHA Univ Coll Med Bundang CHA Hosp Div Cardiol Dept Internal Med Seongnam South Korea;

Seoul Med Ctr Dept Internal Med Div Cardiol Seoul South Korea;

Kyung Hee Univ Hosp Cardiovasc Dept Internal Med Seoul South Korea;

Bundang Jesaeng Hosp Dept Internal Med Div Cardiol Seongnam South Korea;

Seoul Med Ctr Dept Internal Med Div Cardiol Seoul South Korea;

Yonsei Univ Wonju Coll Med Dept Internal Med Div Cardiol Wonju South Korea;

Sungkyunkwan Univ Sch Med Kangbuk Samsung Hosp Div Cardiol Dept Med Seoul South Korea;

Korea Univ Guro Hosp Cardiovasc Ctr Seoul South Korea;

Ajou Univ Med Ctr Dept Cardiol Suwon South Korea;

Hallym Univ Coll Med Kangdong Sacred Heart Hosp Div Cardiol Dept Internal Med Seoul South Korea;

Catholic Univ Dept Internal Med Div Cardiol Seoul South Korea;

Soonchunhyang Univ Hosp Dept Internal Med Div Cardiol Seoul South Korea;

Pusan Natl Univ Hosp Med Res Inst Dept Internal Med Div Cardiol Busan South Korea;

Konyang Univ Hosp Ctr Heart Div Cardiol Daejeon South Korea;

Dongguk Univ Ilsan Hosp Cardiovasc Ctr Goyang South Korea;

Inha Univ Hosp Dept Internal Med Div Cardiol Incheon South Korea;

NHIS llsan Hosp Dept Internal Med Div Cardiol Goyang South Korea;

Catholic Univ Korea St Vincents Hosp Dept Internal Med Div Cardiol Suwon South Korea;

Seoul Natl Univ Coll Med Seoul Natl Univ Hosp Div Cardiol Dept Internal Med Seoul South Korea;

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原文格式 PDF
正文语种 eng
中图分类治疗学;
关键词
ezetimibe; hypercholesterolemia; rosuvastatin; singe-pill combination;

机译：ezetimibe;高胆固醇血症;roosuvastatin;单粒丸组合;

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1. A Phase III, Multicenter, Randomized, Double-blind, Active Comparator Clinical Trial to Compare the Efficacy and Safety of Combination Therapy With Ezetimibe and Rosuvastatin Versus Rosuvastatin Monotherapy in Patients With Hypercholesterolemia: I-ROSETTE (Ildong Rosuvastatin & Ezetimibe for Hypercholesterolemia) Randomized Controlled Trial [J] . Hong Soon Jun, Jeong Han Saem, Ahn Jeong Cheon, Clinical therapeutics . 2018,第2期

机译：III期，多中心，随机，双盲，活性比较试验，以比较与ezetimibe和罗萨凡汀单一的高胆固醇血症患者的疗效和安全性的疗效和安全性：I-ROSETTE（ILDONGROSUVASTATIMIBE用于高胆固醇血症）随机控制审判
2. Efficacy and Safety of Ezetimibe and Rosuvastatin Combination Therapy Versus Those of Rosuvastatin Monotherapy in Patients With Primary Hypercholesterolemia [J] . Kim Woohyeun, Yoon Yeonyee E., Shin Sung-Hee, Clinical therapeutics . 2018,第6期

机译：ezetimibe和roosuvastatin联合治疗的疗效和安全性与原发性高胆固醇血症患者罗萨伐他汀单一治疗的疗效和安全性
3. Efficacy and safety of fixed-dose combination therapy with gemigliptin (50 mg) and rosuvastatin compared with monotherapy in patients with type 2 diabetes and dyslipidaemia (BALANCE): A multicentre, randomized, double-blind, controlled, phase 3 trial [J] . Bae Ji Cheol, Min Kyung Wan, Kim Yong Hyun, Diabetes, obesity & metabolism . 2019,第1期

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6. Efficacy and Tolerability of a Fixed-Dose Combination of Rosuvastatin and Ezetimibe Compared with a Fixed-Dose Combination of Simvastatin and Ezetimibe in Brazilian Patients with Primary Hypercholesterolemia or Mixed Dyslipidemia: A Multicenter Randomized Trial [O] . Antonio Carlos Amedeo Vattimo, Francisco Antonio Helfestein Fonseca, Douglas Costa Morais, 2020

机译：罗苏伐他汀和欧塞蒂米贝的固定剂量组合的疗效和耐受性与司法素和欧洲血管血症患者的辛伐他汀和欧洲血管血症患者的固定剂量组合相比：多中心随机试验
7. A Phase III, Multicenter, Randomized, Double-blind, Active Comparator Clinical Trial to Compare the Efficacy and Safety of Combination Therapy With Ezetimibe and Rosuvastatin Versus Rosuvastatin Monotherapy in Patients With Hypercholesterolemia: I-ROSETTE (Ildong Rosuvastatin Ezetimibe for Hypercholesterolemia) Randomized Controlled Trial [O] . Soon Jun Hong, Han Saem Jeong, Jeong Cheon Ahn, 2018

机译：III期，多中心，随机，双盲，活性比较试验，以比较与ezetimibe和罗萨凡汀单一的高胆固醇血症患者的疗效和安全性的疗效和安全性：I-ROSETTE（ILDONGROSUVASTATIMIBE用于高胆固醇血症）随机控制审判

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