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首页> 外文期刊>Clinical cancer research: an official journal of the American Association for Cancer Research >Sustained Therapeutic Efficacy of Humanized Anti-CD19 Chimeric Antigen Receptor T Cells in Relapsed/Refractory Acute Lymphoblastic Leukemia
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Sustained Therapeutic Efficacy of Humanized Anti-CD19 Chimeric Antigen Receptor T Cells in Relapsed/Refractory Acute Lymphoblastic Leukemia

机译：人源化抗CD19嵌合抗原受体T细胞在复发/难治性急性淋巴细胞白血病中持续治疗疗效

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摘要

Purpose: Immunogenicity derived from the murine scFv, a major molecular compomemt of chimeric antigen receptors (CARs), may limit the persistence of CAR T cells, resulting in tumor relapse of patients in complete remission (CR). In this study, we developed a humanized anti-CD19 scFv CAR-T (hCAR-T) to treat patients with relapsed/refractory acute lymphoblastic leukemia (r/r ALL).
机译：目的：衍生自鼠SCFV的免疫原性，嵌合抗原受体（汽车）的主要分子Compomt可能限制汽车T细胞的持续性，导致完全缓解（Cr）中患者的肿瘤复发。 在这项研究中，我们开发了一种人源化的抗CD19 SCFV Car-T（HCar-T），以治疗复发/难治性急性淋巴细胞白血病（R / R全部）。

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  • 来源
  • 作者

    Heng Gang; Jia Jiankun; Li Shiqi; Fu Gang; Wang Meiling; Qin Dabing; Li Yunyan; Pei Li; Tian Xiaobo; Zhang Jiasi; Wu Yi; Xiang Shali; Wan Jia; Zhu Wei; Zhang Pei; Zhang Qianzhen; Peng Xi; Wang Linling; Wang Ping; Wei Zhihao; Zhang Yingzi; Wang Guiqin; Chen Xue; Zhang Chengcheng; Sun Yanni; Zhao Wenxu; Fan Yahan; Yang Zhi; Chen Jieping; Qian Cheng;

  • 作者单位

    Army Med Univ Ctr Biol Therapy Southwest Hosp Third Mil Med Univ Chongqing Peoples R China;

    Army Med Univ Ctr Biol Therapy Southwest Hosp Third Mil Med Univ Chongqing Peoples R China;

    Army Med Univ Ctr Biol Therapy Southwest Hosp Third Mil Med Univ Chongqing Peoples R China;

    Army Med Univ Ctr Haematol Southwest Hosp Third Mil Med Univ Chongqing Peoples R China;

    Army Med Univ Ctr Biol Therapy Southwest Hosp Third Mil Med Univ Chongqing Peoples R China;

    Army Med Univ Ctr Haematol Southwest Hosp Third Mil Med Univ Chongqing Peoples R China;

    Army Med Univ Ctr Biol Therapy Southwest Hosp Third Mil Med Univ Chongqing Peoples R China;

    Army Med Univ Ctr Haematol Southwest Hosp Third Mil Med Univ Chongqing Peoples R China;

    Army Med Univ Ctr Haematol Southwest Hosp Third Mil Med Univ Chongqing Peoples R China;

    Army Med Univ Ctr Haematol Southwest Hosp Third Mil Med Univ Chongqing Peoples R China;

    Army Med Univ Dept Nephrol Southwest Hosp Third Mil Med Univ Chongqing Peoples R China;

    Army Med Univ Ctr Haematol Southwest Hosp Third Mil Med Univ Chongqing Peoples R China;

    Army Med Univ Ctr Haematol Southwest Hosp Third Mil Med Univ Chongqing Peoples R China;

    Army Med Univ Ctr Biol Therapy Southwest Hosp Third Mil Med Univ Chongqing Peoples R China;

    Army Med Univ Ctr Haematol Southwest Hosp Third Mil Med Univ Chongqing Peoples R China;

    Army Med Univ Ctr Biol Therapy Southwest Hosp Third Mil Med Univ Chongqing Peoples R China;

    Army Med Univ Ctr Haematol Southwest Hosp Third Mil Med Univ Chongqing Peoples R China;

    Army Med Univ Ctr Biol Therapy Southwest Hosp Third Mil Med Univ Chongqing Peoples R China;

    Army Med Univ Ctr Haematol Southwest Hosp Third Mil Med Univ Chongqing Peoples R China;

    Army Med Univ Ctr Biol Therapy Southwest Hosp Third Mil Med Univ Chongqing Peoples R China;

    Army Med Univ Ctr Biol Therapy Southwest Hosp Third Mil Med Univ Chongqing Peoples R China;

    Army Med Univ Ctr Biol Therapy Southwest Hosp Third Mil Med Univ Chongqing Peoples R China;

    Army Med Univ Ctr Haematol Southwest Hosp Third Mil Med Univ Chongqing Peoples R China;

    Army Med Univ Ctr Biol Therapy Southwest Hosp Third Mil Med Univ Chongqing Peoples R China;

    Army Med Univ Ctr Haematol Southwest Hosp Third Mil Med Univ Chongqing Peoples R China;

    Army Med Univ Ctr Biol Therapy Southwest Hosp Third Mil Med Univ Chongqing Peoples R China;

    Army Med Univ Dept Blood Transfus Southwest Hosp Third Mil Med Univ Chongqing Peoples R China;

    Army Med Univ Ctr Biol Therapy Southwest Hosp Third Mil Med Univ Chongqing Peoples R China;

    Army Med Univ Ctr Haematol Southwest Hosp Third Mil Med Univ Chongqing Peoples R China;

    Army Med Univ Ctr Biol Therapy Southwest Hosp Third Mil Med Univ Chongqing Peoples R China;

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  • 正文语种 eng
  • 中图分类 肿瘤学;
  • 关键词

  • 入库时间 2022-08-19 23:44:51

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