Safe and Effective Cardiac Regenerative Therapy With Human-Induced Pluripotent Stem Cells How Should We Prepare Pure Cardiac Myocytes?

摘要

A clinical study on human-induced pluripotent stem cells (hiPSCs) is underway in the ophthalmic field, and patients with advanced heart failure will be among the next targets for cell transplantation with hiPSCs. Although many approaches for production of hiPSC-derived cardiac myocytes (hiPSC-CMs) have been developed, numerous hurdles must be overcome to achieve safe and effective cardiac regenerative therapy (CRT).