An overview of immobilized enzymes used in the industry

摘要

The use of immobilized enzymes is now an established technology for the manufacture of many key Compounds in the pharmaceutical, chemical and food industry. Certain enzymes, such as lipases, are naturally robust and efficient, and are used in immobilized form to produce different molecules for different final applications. More specific enzymes, such as transaminases, which have required protein engineering to become suitable for applications in industrial manufacture; are now utilized in immobilized form in the manufacture of active pharmaceutical ingredients (APIs). For all enzymes, the possibility to be immobilized and used in a heterogeneous form holds significant industrial and environmental advantages such as simplified downstream processing, or continuous process Operations. Here, we present a series of large-scale applications of immobilized enzymes with benefits for the food, chemical, and pharmaceutical industries.