Human mast cells release the migraine-inducing factor pituitary adenylate cyclase-activating polypeptide (PACAP)

摘要

Background Many patients with migraines suffer from allergies and vice versa, suggesting a relationship between biological mechanisms of allergy and migraine. It was proposed many years ago that mast cells may be involved in the pathophysiology of migraines. We set out to investigate the relationship between mast cell activation and known neurogenic peptides related to migraine.