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首页> 外文期刊>Chembiochem: A European journal of chemical biology >New WS9326A Derivatives and One New Annimycin Derivative with Antimalarial Activity are Produced by Streptomyces asterosporusStreptomyces asterosporus DSM 41452 and Its Mutant
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New WS9326A Derivatives and One New Annimycin Derivative with Antimalarial Activity are Produced by Streptomyces asterosporusStreptomyces asterosporus DSM 41452 and Its Mutant

机译：新的WS9326A衍生物和一种新的Annimycin衍生物具有抗疟疾活性的衍生物是由链霉菌孢子孢子孢子生成的，Streptomyces Asterosporus DSM 41452及其突变体

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Abstract > In this study, we report that Streptomyces asterosporus DSM 41452 is a producer of new molecules related to the nonribosomal cyclodepsipeptide WS9326A and the polyketide annimycin. S.?asterosporus DSM 41452 is shown to produce six cyclodepsipeptides and peptides, WS9326A to G. Notably, the compounds WS9326F and WS9326G have not been described before. The genome of S.?asterosporus DSM 41452 was sequenced, and a putative WS9326A gene cluster was identified. Gene‐deletion experiments confirmed that this cluster was responsible for the biosynthesis of WS9326A to G. Additionally, a gene‐deletion experiment demonstrated that sas16 encoding a cytochrome?P450 monooxygenase was involved in the synthesis of the novel ( E )‐2,3‐dehydrotyrosine residue found in WS9326A and its derivatives. An insertion mutation within the putative annimycin gene cluster led to the production of a new annimycin derivative, annimycin?B, which exhibited modest inhibitory activity against Plasmodium falciparum . </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> >在本研究中，我们报告说 Streptomyces Asterosporus </ i> DSM 41452是与非纤维素环脂己二肽WS9326A和聚酮化丙烯酰亚胺有关的新分子的生产者。 S.Asterosporus </ i> DSM 41452显示为产生六个环糊精和肽，WS9326A至G.值得注意的是，之前未描述化合物WS9326F和WS9326G。测序 s.Astosporus孢子孢孢菌41452的基因组，并鉴定了推定的WS9326A基因簇。基因缺失实验证实，该簇对WS9326A至G的生物合成负责。另外，基因缺失实验证明了编码细胞色素的<I> SAS16 </ i>参与新颖的合成（ e </ i>）-2,3-脱氢透明蛋白残基在WS9326A及其衍生物中发现。推定的共享霉素基因簇内的插入突变导致了新的共享霉素衍生物的共安霉素αb，其对I>疟原虫进行了适度的抑制活性。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-16039/'>《Chembiochem: A European journal of chemical biology》</a> <b style="margin: 0 2px;">|</b><span>2018年第3期</span><b style="margin: 0 2px;">|</b><span>共8页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Songya&option=202" target="_blank" rel="nofollow">Zhang Songya;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhu Jing&option=202" target="_blank" rel="nofollow">Zhu Jing;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zechel David L.&option=202" target="_blank" rel="nofollow">Zechel David L.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jessen‐Trefzer Claudia&option=202" target="_blank" rel="nofollow">Jessen‐Trefzer Claudia;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Eastman Richard T.&option=202" target="_blank" rel="nofollow">Eastman Richard T.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Paululat Thomas&option=202" target="_blank" rel="nofollow">Paululat Thomas;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bechthold Andreas&option=202" target="_blank" rel="nofollow">Bechthold Andreas;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Pharmaceutical Biology and BiotechnologyUniversity of FreiburgStefan-Meier-Strasse 19 VF 79104 Freiburg im Breisgau Germany;</p> <p>Department of Pharmaceutical Biology and BiotechnologyUniversity of FreiburgStefan-Meier-Strasse 19 VF 79104 Freiburg im Breisgau Germany;</p> <p>Department of ChemistryQueen's University90 Bader Lane Kingston Ontario K7L 3N6 Canada;</p> <p>Department of Pharmaceutical Biology and BiotechnologyUniversity of FreiburgStefan-Meier-Strasse 19 VF 79104 Freiburg im Breisgau Germany;</p> <p>Division of Pre-Clinical InnovationNational Center for Advancing Translational Sciences/NIH9800 Medical Center Drive Rockville MD 20850 USA;</p> <p>Department of Chemistry and BiologyUniversit?t SiegenAdolf-Reichwein-Strasse 2 57068 Siegen Germany;</p> <p>Department of Pharmaceutical Biology and BiotechnologyUniversity of FreiburgStefan-Meier-Strasse 19 VF 79104 Freiburg im Breisgau Germany;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/179.html" title="分子生物学">分子生物学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=annimycin&option=203" rel="nofollow">annimycin;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=antimalarial activity&option=203" rel="nofollow">antimalarial activity;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=biosynthesis&option=203" rel="nofollow">biosynthesis;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=dehydrotyrosine&option=203" rel="nofollow">dehydrotyrosine;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=mutagenesis&option=203" rel="nofollow">mutagenesis;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=P450 monooxygenase&option=203" rel="nofollow">P450 monooxygenase;</a> </p> <div class="translation"> 机译：Annimycin;抗疟活性;生物合成;Dehydrootyrosine;诱变;P450单氧化酶; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704022055934.html">New WS9326A Derivatives and One New Annimycin Derivative with Antimalarial Activity are Produced by <i >Streptomyces asterosporusStreptomyces asterosporus DSM 41452 and Its Mutant</a> <b>[J]</b> . <span> <a 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manufacture of a Medicament for the treatment of bacterial infections and a Strain of Streptomyces sp.st 108140 (DSM 19369)</a> <b>[P]</b> . <span> 外国专利： <!-- --> AR072624A1 </span> <span> . 2010-09-08</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：雌链螺菌素衍生物，其制备方法，包含其的药物组合物及其在制备用于治疗细菌感染的药物和链霉菌菌株st.108140（DSM 19369）中的用途 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130432838715.html">meridamycin synthase complex, host cell, synthetic polyketide synthase, nucleic acid sequence, recombinant vector, isolated nucleic acid, chimeric nucleic acid construction, methods for producing a polyketide compound and for determining the structural requirement for polyketide activity, meridamycin, mutant streptomyces strain, keto meridamycin c36 or a pharmaceutically acceptable salt thereof, deoximeridamycin compound, 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