Estreptospirol Derivatives, a preparation method thereof, a Pharmaceutical composition containing same and their use in the manufacture of a Medicament for the treatment of bacterial infections and a Strain of Streptomyces sp.st 108140 (DSM 19369)

摘要

A procedure for the preparation of such compounds by Fermenting microorganism Streptomyces sp.St 108140 (DSM 19369) and optionally by deriving the compounds produced by the microorganism, a Pharmaceutical composition comprising at least one Compound of the formula (1), and the use of a compound of the formula (1) for the preparation of a Medicament for the treatment and / or profilaxi S of bacterial infections. The microorganism Strain Streptomyces sp. (DSM 19369 St 108140).Claim 1: a compound of the formula (1) wherein R1 is alkyl (C6 / 7), R2 is H, alkyl (C1 - 6) or alquileno (C1 - 6) - Oh, R3 is H or alkyl (C1 - 6), X1 is Halogen or alkyl (C1 - 6 [alkyl (C1), NH - NH [6]), rent (c1-4) - aryl (C6 NH [10]), rent (c1-4) - (heteroaryl c6-10) or s (C1 - Rent 4 - (alkyl) - N (c1-4)] 2, X2 is Halogen,And Y1 and Y2 are independently of each other (H, o, NH [alkyl (C1 - 6) [Rent]; NH (c1-4) - aryl (C6) 10] in which the aryl Group (C610) optionally replaced by Halogen; NH [Rent (c1-4) - heteroaryl (C610)]; a saturated or unsaturated Heterocyclic Ring System containing 5 to 6 Atom S Ring optionally substituted by alkyl (C1 - 6) in which one or two ring Atoms are n,O or s; OR = Y1 and Y2 Are Together or physiologically tolerated, or Salt of a compound of the formula (1).