PCSK9 regulates expression of scavenger receptors and ox-LDL uptake in macrophages

Ding Zufeng; Liu Shijie; Wang Xianwei; Theus Sue; Deng Xiaoyan; Fan Yubo; Zhou Sichang; Mehta Jawahar L.

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PCSK9 regulates expression of scavenger receptors and ox-LDL uptake in macrophages

机译：PCSK9调节清除剂受体和OX-LDL摄取的表达巨噬细胞

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Aims Proprotein convertase subtilisin/kexin type 9 (PCSK9) has been shown to influence macrophage biology and modulate atherogenesis. We conducted this study to examine the regulation of scavenger receptors (SRs) (LOX-1, SRA, and CD36) and oxidized liporoptein cholesterol (ox-LDL) uptake in macrophages by PCSK9.

机译：目的，已证明Proprotein转化酶枯草杆菌蛋白酶/ kexin型9（PCSK9）影响巨噬细胞生物学和调节血液发生。我们进行了本研究，以检查清除剂受体（SRS）（SRS）（LOX-1，SRA和CD36）的调节，并通过PCSK9氧化在巨噬细胞中的氧化脂醇胆固醇（OX-LDL）摄取。

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来源
《Cardiovascular Research》 |2018年第8期|共9页
作者
Ding Zufeng; Liu Shijie; Wang Xianwei; Theus Sue; Deng Xiaoyan; Fan Yubo; Zhou Sichang; Mehta Jawahar L.;
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作者单位

Univ Arkansas Med Sci Cent Arkansas Vet Healthcare Syst Little Rock AR 72205 USA;

Univ Arkansas Med Sci Cent Arkansas Vet Healthcare Syst Little Rock AR 72205 USA;

Xinxiang Med Univ Henan Key Lab Med Tissue Regenerat Xinxiang 453003 Peoples R China;

Univ Arkansas Med Sci Cent Arkansas Vet Healthcare Syst Little Rock AR 72205 USA;

Beihang Univ Key Lab Biomech &

Mechanobiol Minist Educ Sch Biol Sci &

Med Engn Beijing 100191;

Beihang Univ Key Lab Biomech &

Mechanobiol Minist Educ Sch Biol Sci &

Med Engn Beijing 100191;

Weill Cornell Med Dept Neurol Surg New York NY 10065 USA;

Univ Arkansas Med Sci Cent Arkansas Vet Healthcare Syst Little Rock AR 72205 USA;

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原文格式 PDF
正文语种 eng
中图分类心脏、血管（循环系）疾病;
关键词
PCSK9; Macrophages; LOX-1; SRA; CD36;

机译：PCSK9;巨噬细胞;LOX-1;SRA;CD36;

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专利

1. PCSK9 regulates expression of scavenger receptors and ox-LDL uptake in macrophages [J] . Ding Zufeng, Liu Shijie, Wang Xianwei, Cardiovascular Research . 2018,第8期

机译：PCSK9调节清除剂受体和OX-LDL摄取的表达巨噬细胞
2. NOVEL ELEMENTS LOCATED AT -504 TO -399 BP OF THE PROMOTER REGION REGULATED THE EXPRESSION OF THE HUMAN MACROPHAGE SCAVENGER RECEPTOR GENE IN MURINE MACROPHAGES [J] . Liao HS., Doi T., Emi M., Journal of Lipid Research . 1997,第7期

机译：位于启动子区域的-504至-399 BP的新型元素调节了人类巨噬细胞清道夫受体基因在小鼠巨噬细胞中的表达
3. STRUCTURE OF THE MURINE MACROPHAGE SCAVENGER RECEPTOR GENE AND EVALUATION OF SEQUENCES THAT REGULATE EXPRESSION IN THE MACROPHAGE CELL LINE, P388D(1) [J] . Aftring RP., Freeman MW. Journal of Lipid Research . 1995,第6期

机译：鼠巨噬细胞清除剂受体基因的结构和调节巨噬细胞系中表达的序列评价，P388D（1）
4. Endocytic uptake of advanced glycation endproducts by mouse liver sinusoidal endothelial cells is mediated by a receptor distinct from the class A scavenger receptor [C] . Kenshi Matsumoto, Ryoji Nagai, Kouichi Masunaga, International Symposium on the Maillard Reaction . 2002

机译：通过小鼠肝窦内皮细胞的高胶质摄取晚期糖化型封端是由与清除剂受体不同的受体介导的受体
5. Influence of Physicochemical Properties of Silver Nanoparticles on Mast Cell and Macrophage Uptake and Activation: Role of Scavenger Receptor B1 [D] . Aldossari, Abdullah Ali. 2018

机译：银纳米粒子的理化性质对肥大细胞和巨噬细胞摄取和激活的影响：清道夫受体B1的作用。
6. Vitamin D3 Induces Gene Expression of Ox-LDL Scavenger Receptors in Streptozotocin-Induced Diabetic Rat Aortas: New Insight into the Role of Vitamin D in Diabetic Atherosclerosis [O] . Shahab Alizadeh, Abbas Mirshafiey, Mahmoud Djalali, 2018

机译：维生素D 3诱导链脲佐菌素诱导的糖尿病大鼠主动脉中Ox LDL清道夫受体的基因表达：维生素D在糖尿病动脉粥样硬化中的作用的新见解。
7. GW26-e3941 Urokinase Receptor Accelerates Ox-LDL Uptake and Foam Cell Formation by Upregulating CD36 Expression on Macrophages [O] . Zhang Yan, Chen Wei, Fang Quan 2015

机译：GW26-e3941尿激酶受体通过上调巨噬细胞上的CD36表达来加速Ox-LDL摄取和泡沫细胞形成

PCSK9 regulates expression of scavenger receptors and ox-LDL uptake in macrophages

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