Sensors of Succinate: Neural Stem Cell Grafts Fight Neuroinflammation

摘要

In this issue of Cell Stem Cell, Peruzzotti-Jametti et al. (2018) demonstrate how neural stem cells, transplanted in a mouse model of multiple sclerosis, respond to extracellular succinate and modulate neuroinflammation by releasing anti-inflammatory prostaglandin E2 and scavenging succinate. This mechanismreduces CNS damage and ameliorates motor impairment.