Predictive Value of a Noninvasive Serological Hepatic Fibrosis Scoring System in Cirrhosis Combined with Oesophageal Varices

摘要

Liver cirrhosis, a common chronic liver disease, is caused by long-term or repeated damage to liver tissue due to one or more causes, leading to diffuse degeneration and necrosis of hepatocytes, regenerative nodules, and fibrous tissue hyperplasia. Portal hypertension is observed in the advanced stage of cirrhosis. When the portal vein pressure increases to a certain degree, oesophageal varices can occur, while, in severe cases, oesophageal variceal bleeding will emerge, which is the most common and severe complication of cirrhosis and cirrhotic portal hypertension, as well as the most common cause of death for cirrhosis [1]. In the 1990s, the mortality rate after the onset of oesophageal variceal bleeding was as high as 50% [2]. With the development and advancements of medical technology and equipment, along with a further understanding of the disease, the mortality rate has decreased; however, new statistics indicate that the 6-week mortality rate is still as high as 20% [3]. Digestive endoscopy is considered the gold standard for the screening and diagnosis of oesophageal varices [4].