Speculation of the Time-Dependent Change ofFIB4 Index in Patients with Nonalcoholic Fatty Liver Disease:A Retrospective Study

摘要

Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease worldwide [1-5]. A liver biopsy still remains the gold standard for the diagnosis of nonalcoholic steatohepatitis (NASH), but it is difficult to perform liver biopsies in all patients with NAFLD. Therefore many noninvasive methods for estimating liver fibrosis have been developed; these are direct markers and the scoring systems, such as type IV collagen 7S [6,7], hyaluronic acid [8,9], aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio (AAR) [9,10], NAFLD fibrosis score [11], BARD score [12], NAFIC score [7], and so on.