Oxidative Dehydrosulfurative Azolation of 3,4-Dihydropyrimidin-1H-2-thiones

摘要

Pyrimidine structure is embedded as a privileged scaffold owing to its role as a key binding fragment toward the biological targets in many drug molecules.1 This highly versatile template has directed the extensive research to result in several commercial drugs,such as the hypocholesterolemic agent rosuvastatin(Crestor),the potent anticancer drug imatinib(Gleevec),the tyrosine kinase inhibitor ruxolitinib,and the antifungal agent voriconazole(Figure 1).