Cross-Coupling Reactions of (Z)-2-FIuoro-2-trifluoromethylethenyl Tosylate with Aryl-and Arylethenylboronic Acids

摘要

Organofluorine compounds have received much attention in medicinal, agricultural, and material sciences because they often confer dramatic changes in their chemical, physical, and biological properties. Especially, compounds containing trifluoromethyl group have been widely applied in drug development because of their unique property for the high cross ability of the cell membrane. Therefore, introduction of a trifluoromethyl group into the organic molecules has been an important subject in recent years. Although methods for the trifluoromethylation involving a direct coupling reaction of trifiuoromethylated metal reagents with aryl-or alkenyl halides have been well established in recent years, these methods suffer from low reactivity and low selectivity. An alternative promising