Allogeneic haematopoietic cell transplantation for adult acute myeloid leukaemia in second remission: a retrospective study of the Adult Acute Myeloid Leukaemia Working Group of the Japan Society for Haematopoietic Cell Transplantation ( JSHCT JSHCT )

摘要

Summary To evaluate the outcomes and prognostic factors following allogeneic haematopoietic cell transplantation ( HCT ) for adult acute myeloid leukaemia ( AML ) in second complete remission ( CR 2), we retrospectively analysed the Japanese registration data of 1080 adult AML patients in CR 2 who had received allogeneic HCT . The probability of overall survival and the cumulative incidence of relapse at 3?years was 66% and 19%, respectively. In multivariate analysis, older age, poor cytogenetics and shorter duration of first complete remission were significantly associated with a higher overall mortality. Our data demonstrated the significant efficacy of allogeneic HCT for adult AML in CR 2.