Neuroplin-1 (Nrp1) expression identifies a new subset of CD4(+)CD25(HIGH)FOXP3(+) regulatory T cells (Treg) in human lymph nodes (ln). modulation by pre-operative chemoradiation in cervical cancer (CC)

摘要

In LN, the semaphorin III receptor Nrp1 identifies a Treg population (Nrp11Treg) expressing markers of acti-vated Treg, i.e., CD45RO, HLA-DR and GITR. Nrp11Treg proliferate poorly in vitro, and exert contact-dependent in vitro suppression of CD41 and CD81 T cell proliferation and cytokine secretion. In keeping with their activated phenotype, Nrp11Treg are more efficient than Nrp1-Treg at inducing suppression.