Effects of poloxamer‐based thermo‐sensitive sol–gel agent on urethral stricture after transurethral resection of the prostate for benign prostatic hyperplasia: a multicentre, single‐blinded, randomised controlled trial

摘要

Objective To evaluate the effectiveness of poloxamer‐based thermo‐sensitive sol–gel instillation, after transurethral resection of the prostate ( TURP ), for preventing urethral stricture. Patients and Methods In all, 198 patients underwent TURP for benign prostatic hyperplasia. Recruited patients were randomly divided into two groups: groups A and B. Patients in Group A (100 patients, experimental group) received poloxamer‐based thermo‐sensitive sol–gel instillation and patients in the Group B (98 patients, control group) received lubricant instillation after TURP . Each patient was evaluated at 4 (V1), 12 (V2), and 24?weeks (V3) after TURP. The effectiveness of poloxamer‐based thermo‐sensitive sol–gel instillation was evaluated based on the International Prostate Symptom Score ( IPSS ), IPSS‐Quality of Life (QoL), Overactive bladder questionnaire ( OAB ‐q), maximum urinary flow rate (Q max ), post‐void residual urine volume ( PVR ), and cystoscopy. Results Amongst the initial 198 participants, 80 patients in Group A and 83 in Group B completed the study. There were no significant differences in IPSS ‐QoL and OAB ‐q between the groups. However, Q max was significantly different between groups A and B, at a mean (SD) of 18.92?(9.98) vs 15.58?(9.24)? mL /s ( P ?=?0.028) at 24?weeks after TURP. On cystoscopic examination, urethral stricture after TURP was found in two of the 80 patients in Group A and 10 of 83 in Group B ( P ?=?0.023). Conclusions Poloxamer‐based thermo‐sensitive sol–gel instillation after TURP lowered the incidence of urethral stricture.