Same same but different: Wie Cyano bak - terien ein zentrales Enzym regulieren

摘要

In most bacteria the activity of glutamine synthetase (GS) is regulated by covalent protein modifications. Remarkably, cyanobacteria, which are of increasing interest in biotechnology, have evolved fundamentally different regulatory mechanisms for the same enzyme. This includes GS inhibition by the interaction with small proteins, the inactivating factors (IF). In addition, they evolved unique mechanisms to monitor GS activity and to respond with IF biosynthesis accordingly.