Anti-diabetic effects of Inonotus obliquus polysaccharides in streptozotocin-induced type 2 diabetic mice and potential mechanism via PI3K-Akt signal pathway

摘要

Graphical abstract Display Omitted Highlights ? IOPS exhibited antihyperglycemic effects and improvement of insulin resistance in type 2 diabetic mice. ? IOPS exhibited significant antihyperlipidemic effects by improving the metabolism of serum lipid profiles in type 2 diabetic mice. ? IOPS could protect organ tissues against oxidant damages related to STZ-induced hyperglycemia in mice. ? IOPS ameliorated hyperglycemia in diabetic mice through activation of PI3K-Akt signal pathway. Abstract Polysaccharides are the main components of mushroom Inonotus obliquus ( I. obliquus ) with antihyperglycemic activities. This study was aimed to investigate the anti-diabetic effects and the potential mechanism of I. obliquus polysaccharides (IOPS) in high fat diet and STZ-induced type 2 diabetic mice. Results showed that oral administration of IOPS (900mg/kg) could significantly restore the body and fat mass weight, reduce fasting blood glucose levels, improve glucose tolerance ability, increase hepatic glycogen level and ameliorate insulin resistance compared to those of the control diabetic mice (P ]]>