Is Ki67 prognostic for aggressive prostate cancer? A multicenter real-world study.

Joseph J Fantony; Lauren E Howard; Ilona Csizmadi; Andrew J Armstrong; Amy L Lark; Colette Galet; William J Aronson; Stephen J Freedland

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Is Ki67 prognostic for aggressive prostate cancer? A multicenter real-world study.

机译：KI67是否为侵袭性前列腺癌预后？多中心真实研究。

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To test if Ki67 expression is prognostic for biochemical recurrence (BCR) after radical prostatectomy (RP). Ki67 immunohistochemistry was performed on tissue microarrays constructed from specimens obtained from 464 men undergoing RP at the Durham and West LA Veterans Affairs Hospitals. Hazard ratios (HR) for Ki67 expression and time to BCR were estimated using Cox regression. Ki67 was associated with more recent surgery year (p?

机译：试验如果Ki67表达是在自由基前列腺切除术（RP）后生物化学复发（BCR）的预后。对从Durham和West La Veterans事务医院接受RP的464名男性的试样构建的组织微阵列进行了Ki67免疫组织化学。使用COX回归估计KI67表达和BCR的危险比（HR）。 Ki67与最近的手术年份（P？<0.001），阳性边缘（p？= 0.001）和折叠延伸（p≤x0.001）有关。在中心分析分析中，Ki67表达和BCR的调整后的HR接近西拉的统计学意义（HR：1.54; P？= 0.06），但不是Durham（HR：1.10; P？= 0.74）。这种多机构的“现实世界”研究为KI67预测RP预测结果的预后作用提供了有限的证据。

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来源
《Biomarkers in medicine》 |2018年第7期|共10页
作者
Joseph J Fantony; Lauren E Howard; Ilona Csizmadi; Andrew J Armstrong; Amy L Lark; Colette Galet; William J Aronson; Stephen J Freedland;
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作者单位

Department of Surgery Duke University Medical Center;

Urology Section Durham Veterans Affairs Medical Center Durham;

Department of Surgery Cedars-Sinai Medical Center Los Angeles;

Department of Medicine Duke University School of Medicine;

Department of Pathology Duke University Hospital;

Department of Urology David Geffen School of Medicine University of California at Los Angeles;

Department of Urology David Geffen School of Medicine University of California at Los Angeles;

Urology Section Durham Veterans Affairs Medical Center Durham;

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原文格式 PDF
正文语种 eng
中图分类预防医学、卫生学;
关键词
Ki67; biochemical recurrence; castration-resistant prostate cancer; immunohistochemistry; metastases; prostate cancer; tissue microarray;

机译：KI67;生化复发;抗阉割的前列腺癌;免疫组化;转移;前列腺癌;组织微阵列;

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专利

1. Is Ki67 prognostic for aggressive prostate cancer? A multicenter real-world study. [J] . Joseph J Fantony, Lauren E Howard, Ilona Csizmadi, Biomarkers in medicine . 2018,第7期

机译：KI67是否为侵袭性前列腺癌预后？多中心真实研究。
2. Targeted prostate cancer screening in men with mutations in BRCA1 and BRCA2 detects aggressive prostate cancer: preliminary analysis of the results of the IMPACT study. [J] . Easton DF, Eeles RA BJU international . 2011,第1期

机译：对BRCA1和BRCA2突变的男性进行有针对性的前列腺癌筛查可以检测出侵略性前列腺癌：IMPACT研究结果的初步分析。
3. Intraductal carcinoma of the prostate in prostate biopsy samples: correlation with aggressive pathological features after radical prostatectomy and prognostic value in high-risk prostate cancer [J] . Sha Zhu, Jin-Ge Zhao, Jun-Ru Chen, Asian journal of andrology . 2020,第5期

机译：前列腺活检样品中前列腺内部癌：与高危前列腺癌的自由基前列腺切除术和预后价值发生侵略性病理特征的相关性
4. Identification of aggressive prostate cancer in ex vivo human prostates by physio-chemical photoacoustics [C] . Guan Xu, Shengsong Huang, Yu Qin, IEEE International Ultrasonics Symposium . 2017

机译：用理化光声技术鉴定离体人前列腺中的侵袭性前列腺癌
5. Development of novel biomarkers in cancer: Detection of circulating miR-141 as a potential prognostic marker for prostate cancer. [D] . Gonzales, Jason Cadaoas. 2010

机译：癌症中新型生物标志物的开发：检测循环miR-141作为前列腺癌的潜在预后标志物。
6. Is Ki67 prognostic for aggressive prostate cancer? A multicenter real-world study [O] . Joseph J Fantony, Lauren E Howard, Ilona Csizmadi, -1

机译：Ki67对侵袭性前列腺癌有预后吗？多中心现实世界研究
7. Tumour growth fraction measured by immunohistochemical staining of Ki67 is an independent prognostic factor in preoperative prostate biopsies with small-volume or low-grade prostate cancer [O] . Zellweger, T, Günther, S, Zlobec, I, 2009

机译：通过Ki67免疫组织化学染色测量的肿瘤生长分数是小体积或低度前列腺癌术前前列腺活检中的独立预后因素

Is Ki67 prognostic for aggressive prostate cancer? A multicenter real-world study.

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