Magnesium isoglycyrrhizinate promotes the activated hepatic stellate cells apoptosis via endoplasmic reticulum stress and ameliorates fibrogenesis        <i >in vitroin vitro        and        <i >in vivoin vivo

Bian Mianli; Chen Xingran; Zhang Chenxi; Jin Huanhuan; Wang Feixia; Shao Jiangjuan; Chen Anping; Zhang Feng; Zheng Shizhong

摘要

Abstract > Varied pathogenetic elements have been touched upon the liver fibrosis, including inflammatory, stress, apoptosis and unfolded proteins aggregation. Magnesium Isoglycyrrhizinate (MgIG) has been accepted to be a neuroprotective effect, hepatoprotective and anti‐inflammatory molecule. In our vitro researches, MgIG was considered to activate hepatic stellate cells (HSCs) apoptosis by promoting endoplasmic reticulum stress (ERS) detrimental response to a certain extent. Consequently, MgIG showed its potential therapeutic capacity in fibrogenesis and counteracted the pathogenetic aspects, which were involved in integrating current treatments correcting liver fibrosis. In addition, we further verificated the behavior and pathogenic mechanisms in the CCl <sub>4</sub> ‐induced liver fibrosis in male mice. What surprised us was that with the treatment of MgIG caused the activation of ERS and resisted the activated HSCs in the protective effects on liver damage. We found MgIG significantly promoted the apoptosis of activated HSCs and protected the CCl <sub>4</sub> ‐induced liver fibrosis. Main molecules came down to the unfolded protein response signaling pathway. Furthermore, MgIG inhibited the levels of the downstream inflammatory cytokines, which were triggered by CCl <sub>4</sub> ‐induced liver fibrosis. Here, we reported that MgIG improved behavioral impairments induced by intraperitoneal injection of CCl <sub>4</sub> and decreased the expression of proinflammatory factor, which indicated the preserving effects on liver fibrosis. ? 2017 BioFactors, 43(6):836–846, 2017 </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“main”> <标题类型=“main”>摘要</标题> >在肝纤维化上触及了各种致病元素，包括炎症，应力，细胞凋亡和展开的蛋白质聚集。镁异丙酚（MGIG）被认为是神经保护作用，肝保护和抗炎分子。在我们的体外研究中，MGIG被认为通过在一定程度上促进内质网胁迫（ERS）不利的反应来激活肝星状细胞（HSCs）凋亡。因此，MGIG显示其纤维发生的潜在治疗能力并抵消了致病的致病方面，这些方面涉及校正肝纤维化的当前处理。此外，我们进一步认识了CCL <sub> 4 </ sub>诱导的雄性小鼠肝纤维化的行为和致病机制。我们惊讶的是，随着MGIG的治疗导致激活患者并抵抗活化的HSC对肝损伤的保护作用。我们发现MGIG显着促进了活化HSC的凋亡，并保护了CCL <SUB> 4 </ sub>诱导的肝纤维化。主要分子降至展开的蛋白质响应信号通路。此外，MGIG抑制了下游炎性细胞因子的水平，该细胞因子由CCL <sub> 4 </ sub>诱导的肝纤维化引发。在这里，我们报道了MGIG改善了通过腹腔注射CCL <sub> 4 </ sub的诱导的行为损伤，并降低了促炎症因子的表达，这表明对肝纤维化的保持影响。还2017年生物actors，43（6）：836-846,2017 </ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-14799/'>《BioFactors》</a> <b style="margin: 0 2px;">|</b><span>2017年第6期</span><b style="margin: 0 2px;">|</b><span>共11页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bian Mianli&option=202" target="_blank" rel="nofollow">Bian Mianli;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chen Xingran&option=202" target="_blank" rel="nofollow">Chen Xingran;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Chenxi&option=202" target="_blank" rel="nofollow">Zhang Chenxi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jin Huanhuan&option=202" target="_blank" rel="nofollow">Jin Huanhuan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wang Feixia&option=202" target="_blank" rel="nofollow">Wang Feixia;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Shao Jiangjuan&option=202" target="_blank" rel="nofollow">Shao Jiangjuan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chen Anping&option=202" target="_blank" rel="nofollow">Chen Anping;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Feng&option=202" target="_blank" rel="nofollow">Zhang Feng;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zheng Shizhong&option=202" target="_blank" rel="nofollow">Zheng Shizhong;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Pharmacology School of PharmacyNanjing University of Chinese MedicineNanjing Jiangsu China;</p> <p>Department of Pharmacology School of PharmacyNanjing University of Chinese MedicineNanjing Jiangsu China;</p> <p>Department of Pharmacology School of PharmacyNanjing University of Chinese MedicineNanjing Jiangsu China;</p> <p>Department of Pharmacology School of PharmacyNanjing University of Chinese MedicineNanjing Jiangsu China;</p> <p>Department of Pharmacology School of PharmacyNanjing University of Chinese MedicineNanjing Jiangsu China;</p> <p>Department of Pharmacology School of PharmacyNanjing University of Chinese MedicineNanjing Jiangsu China;</p> <p>Department of Pathology School of MedicineSaint Louis UniversitySt Louis MO;</p> <p>Department of Pharmacology School of PharmacyNanjing University of Chinese MedicineNanjing Jiangsu China;</p> <p>Department of Pharmacology School of PharmacyNanjing University of Chinese MedicineNanjing Jiangsu China;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/177.html" title="生物化学">生物化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=MgIG&option=203" rel="nofollow">MgIG;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=hepatic stellate cells&option=203" rel="nofollow">hepatic stellate cells;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=apoptosis&option=203" rel="nofollow">apoptosis;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=endoplasmic reticulum stress&option=203" rel="nofollow">endoplasmic reticulum stress;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=fibrogenesis&option=203" rel="nofollow">fibrogenesis;</a> </p> <div class="translation"> 机译：mgig;肝星状细胞;细胞凋亡;内质网胁迫;纤维发生; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a 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Magnesium isoglycyrrhizinate promotes the activated hepatic stellate cells apoptosis via endoplasmic reticulum stress and ameliorates fibrogenesis in vitroin vitro and in vivoin vivo

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