Prospective endoscopic ultrasonographic evaluation of the frequency of nonfunctioning pancreaticoduodenal endocrine tumors in patients with multiple endocrine neoplasia Type 1

摘要

Multiple endocrine neoplasia type 1 (MEN1) is a syndrome carrying a hereditary predisposition to endocrine tumors with autosomal-dominant transmission, the gene of which is located on the long arm of chromosome 11 at 11q13. MEN1 is characterized by the appearance in the same subject of neoplastic lesions, functioning or not, in the parathyroids, the anterior pituitary gland, the endocrine pancreas, and/or the duodenum and the adrenals. The frequency of pancreatico-duodenal endocrine tumors in patients with multiple endocrine neoplasia type 1 (MEN1) remains unknown.