Copper-mediated aerobic oxidative synthesis of benzimidazo fused quinazolines via a multicomponent approach

摘要

The first copper mediated aerobic oxidative multi-component synthesis of benzimidazo[1,2-c]quinazolines has been developed from 2-(2-halophenyl)benzoimidazoles, aldehydes and sodium azide as a nitrogen source. This protocol involves the formation of three C-N bonds starting from azidation of haloaryl with sodium azide followed by in situ conversion of azide into arylamine, which on condensation with benzaldehyde undergoes oxidative cyclization to afford benzimidazo[1,2-c]quinazoline in good to excellent yield.