Copper-catalyzed hydroboration of propargyl-functionalized alkynes in water

摘要

The Cu-catalyzed hydroboration of alkynes in operationally simple and environmentally friendly conditions is reported. The reactions are performed in water, at room temperature, under micellar catalysis. Conditions to form the alpha or beta borylated products selectively have been found and as an application a protocol for the tandem hydroboration/Suzuki coupling in water was developed.