Sphingosine Kinase 2 Modulates Retinal Neovascularization in the Mouse Model of Oxygen-Induced Retinopathy

Eresch Jeanette; Stumpf Martin; Koch Alexander; Vutukuri Rajkumar; Ferreiros Nerea; Schreiber Yannick; Schroeder Katrin; Devraj Kavi; Popp Ruediger; Hattenbach Lars-Olof; Pfeilschifter Josef; Pfeilschifter Waltraud

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Sphingosine Kinase 2 Modulates Retinal Neovascularization in the Mouse Model of Oxygen-Induced Retinopathy

机译：鞘氨酸激酶2在氧诱导视网膜病变的小鼠模型中调节视网膜新生血管

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PURPOSE. Neovascularization is a major cause of blindness in various ocular diseases. Bioactive sphingosine 1-phosphate (S1P), synthesized by two sphingosine kinases (Sphk1, Sphk2), emerged as a key player in a multitude of cellular processes, including cell survival, proliferation, inflammation, migration, and angiogenesis. We investigated the role of Sphk2, S1P, and S1P receptors (S1PR) during retinal neovascularization using the oxygen-induced retinopathy mouse model (OIR).

机译：目的。新血管形成是各种眼部疾病失明的主要原因。由两种鞘氨酸激酶（SPHK1，SPHK2）合成的生物活性鞘氨酸1-磷酸（S1P），作为众多细胞过程中的关键参与者，包括细胞存活，增殖，炎症，迁移和血管生成。我们研究了使用氧诱导的视网膜病变小鼠模型（OIR）在视网膜新血管中的SPHK2，S1P和S1P受体（S1PR）的作用。

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《Investigative ophthalmology & visual science》 |2018年第2期|共9页
作者
Eresch Jeanette; Stumpf Martin; Koch Alexander; Vutukuri Rajkumar; Ferreiros Nerea; Schreiber Yannick; Schroeder Katrin; Devraj Kavi; Popp Ruediger; Hattenbach Lars-Olof; Pfeilschifter Josef; Pfeilschifter Waltraud;
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作者单位

Goethe Univ Hosp Pharmazentrum Frankfurt Inst Gen Pharmacol &

Toxicol Frankfurt Germany;

Goethe Univ Hosp Pharmazentrum Frankfurt Inst Gen Pharmacol &

Toxicol Frankfurt Germany;

Goethe Univ Hosp Pharmazentrum Frankfurt Inst Gen Pharmacol &

Toxicol Frankfurt Germany;

Goethe Univ Hosp Pharmazentrum Frankfurt Inst Gen Pharmacol &

Toxicol Frankfurt Germany;

Goethe Univ Hosp Pharmazentrum Frankfurt Inst Clin Pharmacol Frankfurt Germany;

Goethe Univ Hosp Pharmazentrum Frankfurt Inst Clin Pharmacol Frankfurt Germany;

Goethe Univ Inst Cardiovasc Physiol Frankfurt Germany;

Goethe Univ Hosp Pharmazentrum Frankfurt Inst Gen Pharmacol &

Toxicol Frankfurt Germany;

German Ctr Cardiovasc Res DZHK Partner Site RheinMain Frankfurt Germany;

Ludwigshafen Hosp Dept Ophthalmol Ludwigshafen Germany;

Goethe Univ Hosp Pharmazentrum Frankfurt Inst Gen Pharmacol &

Toxicol Frankfurt Germany;

Goethe Univ Hosp Dept Neurol Theodor Stern Kai 7 D-60590 Frankfurt Germany;

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正文语种 eng
中图分类眼科学;
关键词
lipid signaling; S1P; OIR; sphingosine kinase 2; S1PRs;

机译：脂质信号;S1P;oir;鞘氨酸激酶2;s1prs;

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1. Sphingosine Kinase 2 Modulates Retinal Neovascularization in the Mouse Model of Oxygen-Induced Retinopathy [J] . Eresch Jeanette, Stumpf Martin, Koch Alexander, Investigative ophthalmology & visual science . 2018,第2期

机译：鞘氨酸激酶2在氧诱导视网膜病变的小鼠模型中调节视网膜新生血管
2. Sphingosine Kinase 2 Modulates Retinal Neovascularization in the Mouse Model of Oxygen-Induced Retinopathy [J] . Jeanette Eresch, Martin Stumpf, Alexander Koch, Investigative ophthalmology & visual science . 2018,第2期

机译：鞘氨酸激酶2在氧诱导视网膜病变的小鼠模型中调节视网膜新生血管
3. RhoA activation and effect of Rho-kinase inhibitor in the development of retinal neovascularization in a mouse model of oxygen-induced retinopathy. [J] . Fang X, Ueno M, Yamashita T, Current Eye Research . 2011,第11期

机译：在氧引起的视网膜病变的小鼠模型中，RhoA激活和Rho激酶抑制剂在视网膜新血管形成发展中的作用。
4. Fractal analysis of neovascularization due to diabetic retinopathy in retinal fundus images [C] . Sathvika Mudigonda, Faraz Oloumi, Kalyana M. Katta, IEEE International Conference on E-Health and Bioengineering . 2015

机译：糖尿病性视网膜病在视网膜眼底图像中新生血管形成的分形分析
5. Mouse model for muscle specific kinase (MUSK)-induced myasthenia gravis, and, Direct protein interactions modulate the gating and trafficking of large conductance (BK) calcium-activated potassium channels [D] . Jha, Smita 2008

机译：肌肉特异性激酶（MUSK）引起的重症肌无力的小鼠模型，直接蛋白相互作用调节大电导（BK）钙激活钾通道的门控和转运
6. Activation of retinal microglia rather than microglial cell density correlates with retinal neovascularization in the mouse model of oxygen-induced retinopathy [O] . Franziska Fischer, Gottfried Martin, Hansjürgen T Agostini 2011

机译：在氧引起的视网膜病变的小鼠模型中视网膜小胶质细胞的激活而不是小胶质细胞密度与视网膜新血管形成有关
7. Activation of retinal microglia rather than microglial cell density correlates with retinal neovascularization in the mouse model of oxygen-induced retinopathy [O] . Martin Gottfried, Fischer Franziska, Agostini Hansjürgen T 2011

机译：在氧引起的视网膜病变的小鼠模型中，视网膜小胶质细胞的激活而不是小胶质细胞密度与视网膜新血管形成有关

Sphingosine Kinase 2 Modulates Retinal Neovascularization in the Mouse Model of Oxygen-Induced Retinopathy

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