Zirconyl(IV) Chloride - Catalysed Reaction of Indoles: An Expeditious Synthesis of Bis(indolyl)Methanes

摘要

Zirconyl(IV) chloride is found to be an efficient catalyst for the electrophilic substitution reaction of indole with aldehydes / ketones to afford the corresponding bis(indolyl)methanes in good yields.The remarkable features of this new procedure are high conversions,shorter reaction times,cleaner reaction profiles and simple experimental and work-up procedures.