A series of bis(indolyl)alkane derivatives(3a~3g) were synthesized by the reaction of al-dehydes(1a~1g) with indole(2), using I2 loaded montmorillonite(MMT/I2) as catalyst. The struc-tures were confirmed by 1 H NMR and IR. Effects of catalyst, solvent, reaction time, reaction tempera-ture and mole ratio r[n(1) :n(2)] were investigated, using synthesis of 3a as the template reaction. The yields of 3a~3g were 67. 9% ~96. 2% under the optimum conditions(21 mmol, r=1. 1 :2. 0, 10 mol%MMT/I2 , acetonitrile 1 mL, reaction at 25 ℃ for 5 min). The yield of 3a was 78. 6% after MMT/I2 recycle for three times.%以蒙脱土负载碘(MMT/I2)作催化剂,醛(1a~1g)与吲哚(2)反应合成双吲哚甲烷衍生物(3a~3g),其结构经1H NMR和IR确证.以3a的合成为例,研究了催化剂、溶剂、反应时间、温度和物料比r[n(1):n(2)]对3产率的影响.结果表明:在最佳合成条件(21 mmol,r=1.1:2.0,10 mol%MMT/I2,乙腈1 mL,于25℃反应5 min)下,3a~3g产率67.9%~96.2%.MMT/I2循环使用3次,3a产率78.6%.
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