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首页> 外文期刊>Biosensors & Bioelectronics: The International Journal for the Professional Involved with Research, Technology and Applications of Biosensers and Related Devices >Towards the real-time monitoring of glucose in tear fluid: Holographic glucose sensors with reduced interference from lactate and pH
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Towards the real-time monitoring of glucose in tear fluid: Holographic glucose sensors with reduced interference from lactate and pH

机译:致力于实时监测泪液中的葡萄糖:全息葡萄糖传感器,减少了乳酸和pH的干扰

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摘要

Glucose-selective holographic sensors were fabricated from unique tetrahedral 2-acrylamidophenylboronic acid (2-APB) incorporated with co-monomers poly(ethylene glycol) acrylate (PEG), (3-acrylamidopropyl)trimethylammonium chloride (ATMA) and [2-(acryloyloxy)ethyl]-trimethylammonium chloride (AETA) into thin hydrogel films which were transformed into volume holograms using a diffusion method coupled with holographic recording using a frequency-doubled Nd:YAG laser (532nm). The results showed that the 2-APB-based holographic sensors contracted upon addition of glucose due to the formation of a 2:1 complex between the tetrahedral 2-APB and glucose. More significantly, the 2-APB-based holographic sensors had greatly reduced lactate dependence and a hugely reduced pH effect over the physiological range of pH. These features are vital for development of contact lens-based glucose sensor, where the pH variability is greater (pH 5.8-7.8) and the lactate concentration is substantially higher than in blood. Furthermore, the 2-APB-based holographic sensors also displayed fast response to glucose. The successful union of holograms and the tetrahedral 2-APB receptor for glucose detection in artificial tear fluid is also demonstrated. This new type of holographic sensors responding to glucose with features of minor pH effect and negligible interference from lactate is applicable to the detection of glucose concentrations in tear fluid for the management of diabetes. (C) 2007 Published by Elsevier B.V.
机译:葡萄糖选择性全息传感器由独特的四面体2-丙烯酰胺基苯基硼酸(2-APB)与共聚单体聚(乙二醇)丙烯酸酯(PEG),(3-丙烯酰胺基丙基)三甲基氯化铵(ATMA)和[2-(丙烯酰氧基)乙基]-三甲基氯化铵(AETA)制成水凝胶薄膜,然后使用扩散方法结合倍频Nd:YAG激光(532nm)全息记录,将其转化为体积全息图。结果表明,由于四面体2-APB和葡萄糖之间形成了2:1的络合物,因此添加葡萄糖后,基于2-APB的全息传感器会收缩。更重要的是,基于2-APB的全息传感器在生理pH范围内大大降低了乳酸依赖性,并大大降低了pH效应。这些特性对于开发基于隐形眼镜的葡萄糖传感器至关重要,在该传感器中,pH变异性更大(pH 5.8-7.8),并且乳酸浓度大大高于血液中的乳酸浓度。此外,基于2-APB的全息传感器还显示了对葡萄糖的快速响应。还证明了全息图和四面体2-APB受体在人工泪液中检测葡萄糖的成功结合。这种新型的全息传感器可对葡萄糖作出反应,具有较小的pH效应和可忽略的乳酸盐干扰特性,适用于检测泪液中的葡萄糖浓度,以控制糖尿病。 (C)2007由Elsevier B.V.发布

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