Development of temperature stabilization system for biological sample's microscope

摘要

This paper deals with the development proposal of a heating system for maintaining a required temperature of a microscopic biological sample, which are located within the detection area of the microscope. The need for maintaining a specific temperature of a biological sample is given by the viability of the microorganism what is related to the temperature of their internal medium. Meeting the conditions for changing or maintaining the required temperature is especially necessary in cases such as monitoring the growth of microorganisms and within the temperature-dependent mutations. In this paper, several alternatives are presented, while the best possible design of the heating element is investigated through thermal simulation analysis. Consequently, the proposal for an appropriate control algorithm for the selected heating system and its arrangement is given together with its verification within the experimental sample of the microscope.