y Solubility of 2,4,7-Triamino-6-phenylpteridine (Triamterene, Diuretic Drug) in Supercritical Carbon Dioxide: Experimental Data and Modeling

摘要

In order to design and perform the processes of nano- and microparticle production via supercritical carbon dioxide (SC-CO2), solubility data information of a solid solute such as a pharmaceutical component in SC-CO2 is principally needed. Therefore, a drug solubility, 2,4,7-triamino-6-phenylpteridine (TRM), in SC-CO2 was determined at 308, 318, and 328 to 338 K from 12 to 27 MPa in the present study. Solubility in the mole fraction of TRM in SC-CO2 ranged between 0.42 x 10(-5) and 1.83 x 10(-5), 0.32 x 10(-5) and 2.13 x 10(-5), 0.09 x 10(-5) and 2.34 x 10(-5), and 0.03 x 10(-5) and 2.89 x 10(-5) at 308, 318, 328, and 338 K, respectively. According to the results, solubility data had correlation to the PengRobinson equation of state along with two parameters of van der Waals mixing rules and with models proposed by Mendez-Santiago and Teja, reformulated Charstil, Garlapati and Madras, Bian et al., Chrastil, Bartle et al., Sodeifian et al., and Tippana and Garlapati. It was found that correlation constants were temperature-independent in each model. Further, thermodynamic parameters such as heat of reaction, sublimation, and solvation of the compound were estimated.