Preparation Method of the Inclusion Complex of Peracetylated Cyclodextrin and Water-Soluble Drugs formed in Supercritical Carbon Dioxide and Use Thereof

摘要

PURPOSE: A method for manufacturing an inclusion complex of peracetylated cyclodextrin or heptakis(2,3,6-tri-O-acetyl) cyclodextrin and soluble drugs is provided to enhance inclusion rate and to apply in oral administration. CONSTITUTION: A method for manufacturing an inclusion complex of peracetylated cyclodextrin and soluble drugs comprises: a step of stirring peracetylated cyclodextrin(PAc-CD) and soluble drugs to form an inclusion; a step of removing supercritical carbon dioxide. Peraceylated cyclodextrin is PAc-alpha-CD, PAc-beta-CD, or PAc-gamma-CD. A pharmaceutical composition contains the inclusion complex.