Inclusion Complex Formation of Water- soluble Drug, Captopril, and Peracetylated-β-Cyclodextrin in Supercritical CO_2 for Controlled Release Applications

摘要

The inclusion complex of CO_2-soluble peracetylated-β-cyclodextrin (PAc-β-CD), heptakis(2,3,6-tri-O-acetyl)-β-cyclodextrin, and highly water-soluble drug captopril, was prepared by a chemical solvent-free method using supercritical carbon dioxide. The captopril-PAc-β-CD inclusion complex was further confirmed by DSC and XRD studies. In- vitro release of captopril from an oily suspension confirmed that the dissolution rate of captopril was much retarded from the inclusion complex as a result of the hydrophobic properties of PAc-β-CD.