Determination of the Solubility of the Repaglinide Drug in Supercritical Carbon Dioxide: Experimental Data and Thermodynamic Modeling

摘要

In the recent few years, the measurement, correlation, and calculation of solid solubility, especially drugs, in supercritical fluids have been increased. Evaluation of solubility of a solid solute drug in supercritical fluids is a major factor in the production of nanosized particles. In this research, the solubility of repaglinide (RPL; antidiabetic drug) was measured for the first time. Experiments was fulfilled at various temperatures (308-338 K) and pressures (120-270 bar). It was found that the solubility of RPL is within the range of 2.899 × 10~(-6) to 9.529 × 10~(-5). Peng-Robinson and UNIQUAC as well as six semi-empirical models, including Sodeifian et al., Bartle et al., Chrastil, Mendez-Santiago-Teja, Garlapati-Madras, and Kumar-Johnston, was applied to model the solubility behavior. Moreover, self-consistency tests were carried out to discover the RPL solubility in SC-CO2. Finally, the approximate values of total (ΔH_(total)), vaporization (ΔH_(vap)), and solvation (ΔH_(sol) enthalpies were computed.