Resuscitation strategies in trauma: Commentary

摘要

In the February 2013 issue of JAMA Surgery, Holcomb et al present the results of the PROMMTT (Prospective, Observational, Multicenter, Major Trauma Transfusion) study, an epidemiologic observational cohort study documenting die timing of blood component transfusions during active resuscitation after injury with significant blood loss. The goal was to delineate die association of early transfusion of plasma, platelets, or both and die time-variable ratios of plasma to packed red blood cells (pRBCs) and platelets to pRBCs to bodi early (6-hour) and late (24-hour) mortality in a critically ill patient population. Hemorrhage is the primary preventable cause of mortality for severely injured patients who survive to reach hospital care.2 Because of ongoing improvements in trauma care and trauma systems, the overall mortality of injured patients admitted to a typical level I trauma center has been reduced to 3% to 4%.