The Diagnosis and Treatment of Cardiac Ion Channelopathies: Congenital Long QT Syndrome and Brugada Syndrome

摘要

Sudden cardiac death in young adults can be due to a range of conditions includ-ing coronary disease,hypertrophic or dilated cardiomyopathy,and arrhythmogen-ic right ventricular cardiomyopathy.Although each of these disorders has typicalpathologic findings,some victims display no overt abnormalities and are presumed to have died from a primary cardiac arrhythmia.Increasingly,these malignant ar-rhythmias have been demonstrated to be due to mutations in ion channels.In this review we focus on the two most common of these disorders,termed ion channelo-pathies.namely congenital long Q1 syndrome and Brugada syndrome.