TEMPO-Catalyzed Oxidation of 3-O-Benzylated/Silylated Glycals to the Corresponding Enones Using a PIFA-Water Reagent System

摘要

A simple, highly efficient and regiospecific method for the direct conversion of 3-O-benzylated as well as silylated glycals into the corresponding enones has been developed using PIFA-TEMPO and water reagent system. The reaction is scalable on a gram scale under mild conditions with a yield up to 86%.