Role of Antibodies in Protection Against Ebola Virus in Nonhuman Primates Immunized With Three Vaccine Platforms

Warfield Kelly L.; Howell Katie A.; Hong Vu; Geisbert Joan; Wong Gary; Shulenin Sergey; Sproule Stephanie; Holtsberg Frederick W.; Leung Daisy W.; Amarasinghe Gaya K.; Swenson Dana L.; Bavari Sina; Kobinger Gary P.; Geisbert Thomas W.; Aman M. Javad

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Role of Antibodies in Protection Against Ebola Virus in Nonhuman Primates Immunized With Three Vaccine Platforms

机译：用三种疫苗平台免疫抗埃博拉病毒抗体对埃博拉病毒的作用

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Background Several vaccine platforms have been successfully evaluated for prevention of Ebola virus (EBOV) disease (EVD) in nonhuman primates and humans. Despite remarkable efficacy by multiple vaccines, the immunological correlates of protection against EVD are incompletely understood.

机译：背景技术已经成功评估了几种疫苗平台，以预防非人类灵长类动物和人类的埃博拉病毒（EBOV）疾病（EVD）。尽管多种疫苗效果显着，但对EVD的保护免疫相关性不完全理解。

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来源
《The Journal of Infectious Diseases》 |2018年第5期|共12页
作者
Warfield Kelly L.; Howell Katie A.; Hong Vu; Geisbert Joan; Wong Gary; Shulenin Sergey; Sproule Stephanie; Holtsberg Frederick W.; Leung Daisy W.; Amarasinghe Gaya K.; Swenson Dana L.; Bavari Sina; Kobinger Gary P.; Geisbert Thomas W.; Aman M. Javad;
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作者单位

Integrated BioTherapeut Inc Rockville MD USA;

Integrated BioTherapeut Inc Rockville MD USA;

Integrated BioTherapeut Inc Rockville MD USA;

Univ Texas Med Branch Galveston TX 77555 USA;

Publ Hlth Agcy Canada Special Pathogens Program Natl Microbiol Lab Winnipeg MB Canada;

Integrated BioTherapeut Inc Rockville MD USA;

Optimum Stat Inc Winnipeg MB Canada;

Integrated BioTherapeut Inc Rockville MD USA;

Washington Univ Sch Med Dept Pathol St Louis MO 63110 USA;

Washington Univ Sch Med Dept Pathol St Louis MO 63110 USA;

US Army Med Res Inst Infect Dis Frederick MD USA;

US Army Med Res Inst Infect Dis Frederick MD USA;

Publ Hlth Agcy Canada Special Pathogens Program Natl Microbiol Lab Winnipeg MB Canada;

Univ Texas Med Branch Galveston TX 77555 USA;

Integrated BioTherapeut Inc Rockville MD USA;

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原文格式 PDF
正文语种 eng
中图分类传染病;
关键词
adenovirus; Ebola virus; immune correlate; vaccine; virus-like particles;

机译：腺病毒;埃博拉病毒;免疫相关;疫苗;病毒样粒子;

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专利

1. Role of Antibodies in Protection Against Ebola Virus in Nonhuman Primates Immunized With Three Vaccine Platforms [J] . Warfield Kelly L., Howell Katie A., Hong Vu, The Journal of Infectious Diseases . 2018,第Suppla5期

机译：用三种疫苗平台免疫抗埃博拉病毒抗体对埃博拉病毒的作用
2. A Kunjin Replicon Virus-like Particle Vaccine Provides Protection Against Ebola Virus Infection in Nonhuman Primates [J] . Pyankov Oleg V., Bodnev Sergey A., Pyankova Olga G., The Journal of Infectious Diseases . 2015,第Suppla2期

机译：一种昆金复制子病毒样颗粒疫苗可防止非人类灵长类动物感染埃博拉病毒。
3. Adenovirus-Vectored Vaccine Provides Postexposure Protection to Ebola Virus-Infected Nonhuman Primates [J] . Wong Gary, Richardson Jason S., Pillet Stephane, The Journal of Infectious Diseases . 2015,第Suppla2期

机译：腺病毒载体疫苗为埃博拉病毒感染的非人类灵长类动物提供暴露后保护
4. Evaluation of R_2* as a noninvasive endogenous imaging biomarker for Ebola virus liver disease progression in nonhuman primates [C] . Marcelo A. Castro, Ji Hyun Lee, Ian Crozier, Conference on Medical Imaging : Biomedical Applications in Molecular, Structural, and Functional Imaging . 2020

机译：r_2 *作为非洲原始工具中埃博拉病毒肝病进展的非侵入内源性成像生物标志物的评价
5. Defining the Role of Antibodies in Protection Against Cytomegalovirus Acquisition and Congenital Disease for Rational Vaccine Design [D] . Nelson, Cody S. 2018

机译：定义抗体在患有患有合理疫苗设计中的缩细胞病毒的癌症和先天性疾病的作用
6. Antibody Quality and Protection from Lethal Ebola Virus Challenge in Nonhuman Primates Immunized with Rabies Virus Based Bivalent Vaccine [O] . Joseph E. Blaney, Andrea Marzi, Mallory Willet, 2013

机译：狂犬病病毒二价疫苗免疫的非人类灵长类动物的抗体质量和对埃博拉病毒致死的防护
7. Antibody quality and protection from lethal Ebola virus challenge in nonhuman primates immunized with rabies virus based bivalent vaccine. [O] . Joseph E Blaney, Andrea Marzi, Mallory Willet, 2013

机译：抗体质量和对基于狂犬病病毒的二价疫苗免疫的非人灵长类动物的致命埃博拉病毒攻击的保护。
8. Vaccine to Confer to Nonhuman Primates Complete Protection Against Multistrain Ebola and Marburg Virus Infections. [R] . Swenson, D. L., Wang, D., Luo, M., 2008

机译：授予非人类灵长类动物的疫苗可完全防止多种埃博拉和马尔堡病毒感染。

Role of Antibodies in Protection Against Ebola Virus in Nonhuman Primates Immunized With Three Vaccine Platforms

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