CD8(+)CD28(+)CD127(IO) lo CD39(+) regulatory T-cell expansion: A new possible pathogenic mechanism for HIV infection?

摘要

Background: HIV-associated immunodeficiency is related to loss of CD4(+) T cells. This mechanism does not explain certain manifestations of HIV disease, such as immunodeficiency events in patients with greater than 500 CD4(+) T cells/mL. CD8(+) CD28(-) CD127(lo) CD39(+) T cells are regulatory T (Treg) lymphocytes that are highly concentrated within the tumor microenvironment and never analyzed in the circulation of HIV-infected patients.